A selective Fluorescence Chemosensor: Pyrene motif Schiff base derivative for detection of Cu2+ ions in living cells

被引：31
作者：
Saravanan, Arjunan [1 ]
Subashini, Gopalan [2 ]
Shyamsivappan, Selvaraj [2 ]
Suresh, Thangaraj [2 ]
Kadirvelu, Krishna [1 ]
Bhuvanesh, Nanjan [3 ]
Nandhakumar, Raju [3 ]
Mohan, Palathurai Subramaniam [2 ]
机构：
[1] DRDO BU CLS, Bharathiar Univ Campus, Coimbatore 641046, Tamil Nadu, India
[2] Bharathiar Univ, Sch Chem Sci, Coimbatore 641046, Tamil Nadu, India
[3] Karunya Inst Technol & Sci, Dept Chem, Coimbatore 641114, Tamil Nadu, India
来源：
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY | 2018年 / 364卷
关键词：
Pyrene; Chemosensor; Copper ion; DFT calculation; Bioimaging; SENSITIVE DETECTION; COPPER; CU(II); PROBE; RECOGNITION; ALZHEIMERS; PLATFORM; SENSORS; BINDING; PRION;
D O I：
10.1016/j.jphotochem.2018.06.021
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
A Schiff-base molecule, pyrene motif chemosensor 1 has been synthesized and performed for the fluorescent detection of Cu2+ ions via the inhibition of the photoinduced electron transfer (PET) process. Results were observed the exceptional selectivity towards Cu2+ in DMSO-H2O, (1:1 v/v, HEPES = 50 mM, pH = 7.4) and the association constant (K-a) for chemosensor 1 was binding to Cu2+ system have a value of 1.16 x 10(4) M-1. In addition, the chemosensor 1 has been used as a fluorescence probe for detecting Cu2+ ions in living cells and its binding phenomenon abilities were confirmed by bio-imaging and spectroscopic methods.
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收藏
页码：424 / 432
页数：9
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