Sex bias in alcohol research: A 20-year comparative study

被引：4

作者：

Li, Mianhuan ^{[1
,2
,3
]}

Qu, Yibo ^{[4
,5
]}

Zhong, Jiajun ^{[2
,3
]}

Che, Zhaodi ^{[2
,3
]}

Wang, Hua ^{[6
]}

Xiao, Junjie ^{[7
]}

Wang, Fei ^{[8
]}

Xiao, Jia ^{[2
,3
]}

机构：

[1] Southern Univ Sci & Technol, Shenzhen Peoples Hosp 3, Natl Clin Res Ctr Infect Dis, Hosp Affiliated 2, Shenzhen, Peoples R China

[2] Jinan Univ, Clin Med Res Inst, Affiliated Hosp 1, 601 Huangpu Ave West, Guangzhou 510632, Peoples R China

[3] Jinan Univ, Dept Metab & Bariatr Surg, Affiliated Hosp 1, Guangzhou 510632, Peoples R China

[4] Jinan Univ, Guangdong Hongkong Macau Inst CNS Regenerat, Key Lab CNS Regenerat, Minist Educ, Guangzhou, Peoples R China

[5] Nantong Univ, Coinnovat Ctr Neuroregenerat, Nantong, Jiangsu, Peoples R China

[6] Anhui Med Univ, Affiliated Hosp 1, Dept Oncol, Inst Liver Dis, Hefei, Peoples R China

[7] Shanghai Univ, Sch Life Sci, Cardiac Regenerat & Ageing Lab, Shanghai, Peoples R China

[8] Sun Yat Sen Univ, Div Gastroenterol, Affiliated Hosp 7, 628 Zhenyuan Rd, Shenzhen 518106, Peoples R China

来源：

FRONTIERS IN NEUROENDOCRINOLOGY | 2021年 / 63卷

基金：

中国国家自然科学基金;

关键词：

Alcohol research; Sex bias; Sex-based analysis; Human study; Animal study; GENDER; CONSUMPTION; INCLUSION; WOMENS; POLICY; CYCLE; NIH; DRINKING; DISEASE; TRIALS;

D O I：

10.1016/j.yfrne.2021.100939

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We aimed to assess the sex-inclusive and sex-based analysis bias in alcohol research for the past 20 years. Data were abstracted from 2988 original research articles published from 2000 through 2019 in 51 representative journals across 9 biomedical disciplines. An analysis in 5-year intervals revealed that the percentage of studies using participants of both sexes was significantly higher between 2015 and 2019 than between 2000 and 2014. When stratified, clinical studies showed a higher percentage of both-sex studies compared to basic studies using animals. The reasons for the use of single-sex cohorts mainly included insufficient participant numbers and misconceptions surrounding the hormonal variability of females. Implementation of the NIH SABV policy promoted the ratio of NIH-funded papers with sex-based analyses. In conclusion, sex bias in alcohol-related biomedical studies has improved over the past 20 years, particularly after the implementation of the SABV policy. Although clinical studies increasingly included sex-based analysis, basic studies were biased towards the use of males.

引用

页数：9

共 52 条

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