OXIDATIVE STRESS-INDUCED ALTERATIONS IN FIBROBLAST PLASMA MEMBRANE LIPIDS

被引：0

作者：

Damianova, Ralitza ^{[1
]}

Lupanova, Teodora ^{[2
]}

Petkova, Diana ^{[2
]}

Markovska, Tania ^{[2
]}

Ivanova, Lidia ^{[2
]}

Staneva, Galya ^{[2
]}

Wolf, Claude ^{[3
]}

Pankov, Roumen ^{[1
]}

Momchilova, Albena ^{[2
]}

机构：

[1] St Kl Ohridski Univ Sofia, Fac Biol, Sofia 1164, Bulgaria

[2] Bulgarian Acad Sci, Inst Biophys, BU-1113 Sofia, Bulgaria

[3] INSERM, Fac Med St Antoine, U538, F-75571 Paris 12, France

来源：

COMPTES RENDUS DE L ACADEMIE BULGARE DES SCIENCES | 2010年 / 63卷 / 09期

关键词：

lipid peroxidation; raft microdomains; plasma membrane lipids; PEROXIDATION; CHOLESTEROL;

D O I：

暂无

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The alterations in the lipid composition and the raft microdomain content in plasma membranes of fibroblasts exposed to oxidative attack have been investigated. The results show that treatment of cells with hydrogen peroxide induces reduction of the raft microdomain lipid components, sphingomyelin and cholesterol, as well as of some of the most unsaturated phospholipids phosphatidylserine and phosphatidylethanolamine. The eventual protective role of sphingomyelin against oxidative damage of plasma membrane lipids has been tested by treatment of cells with sphingomyelinase, which selectively hydrolyzes membrane sphingomyelin. An inversely proportional correlation has been established between the level of lipid peroxides and the relative content of raft microdomains.

引用

页码：1321 / 1326

页数：6

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