18F-Flourodeoxy glucose PET-computed tomography in testicular carcinoma: diagnostic and prognostic value

Aim This study aims to assess the diagnostic role of F-18-FDG PET/computed tomography in primary staging and restaging of testicular cancer in comparison with contrast-enhanced diagnostic thoracic-abdominopelvic computed tomography. Material and method Thirty-two consecutive male patients with testicular carcinoma (median age: 29, minmax: 17-65) who were referred to the nuclear medicine department for F-18-FDG PET/computed tomography were retrospectively included in the study. Patients were evaluated based on the F-18-FDG PET/computed tomography indications and germ cell tumor subtypes. Results On patient-based analysis, overall sensitivity, specificity, PPV, NPV and accuracy of F-18-FDG PET/computed tomography were 71%, 100%, 100%, 30% and 75%. On lesion-based analysis, for evaluation of lymph node metastasis they were 76%. 100%, 100%, 57% and 81%, and for detection of distant metastasis 85%, 100%, 100%, 90% and 93%. respectively. Median SUVmax for seminomas were calculated as 14.2 and for nonseminomas 7.8 (P= 0.62) Mean time to progression and overall survival were calculated as 76.6 +/- 10.7 and 111 +/- 7.5 months, respectively. Mean overall survival and time to progression for PET-positive and negative groups was not found significant (P= 0.69 and P= 0.81). The only significant factor in predict overall survival was the presence of distant organ metastases in PET/computed tomography (124.6 +/- 5.2 vs. 78.7 +/- 14.0 months. P= 0.02). Conclusion In this single-center experience with a limited number of patients, F-18-FDG PET/computed tomography appears to have a value of staging and restaging for both seminomatous and non-seminomatous GCTs. Copyright (C) 2019 Wolters Kluwer Health, Inc. All rights reserved.