N-Benzylsalicylthioamides as novel compounds with promising antimycotic activity

被引：3
|
作者：
Petrlikova, Eva [1 ]
Waisser, Karel [1 ]
Buchta, Vladimir [2 ,3 ]
Jilek, Petr [3 ]
Vejsova, Marcela [3 ]
机构：
[1] Charles Univ Prague, Dept Inorgan & Organ Chem, Fac Pharm Hradec Kralove, Hradec Kralove 50003, Czech Republic
[2] Univ Hosp, Dept Clin Microbiol, Hradec Kralove 50005, Czech Republic
[3] Charles Univ Prague, Dept Biol & Med Sci, Fac Pharm Hradec Kralove, Hradec Kralove 50003, Czech Republic
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 15期
关键词：
N-Benzylsalicylthioamides; Antifungal activity; QSAR; Lipophilicity; FUNGAL-INFECTIONS; MYCOSES; HOST;
D O I：
10.1016/j.bmcl.2010.06.023
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The in vitro biological activity of N-benzylsalicylthioamides was evaluated against eight fungal strains by the broth microdilution method and the results were compared with those obtained with fluconazole. The compounds exhibited an in vitro antifungal activity against the fluconazole-susceptible as well as the fluconazole-resistant fungal strains. The biological activity was analyzed by quantitative structure-activity relationship (QSAR). (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4535 / 4538
页数：4
相关论文
共 50 条
  • [21] Novel and promising compounds to treat Cryptosporidium parvum infections
    Zofi Graczyk
    Lidia Chomicz
    Mariola Kozłowska
    Zygmunt Kazimierczuk
    Thaddeus K. Graczyk
    Parasitology Research, 2011, 109 : 591 - 594
  • [22] Novel compounds with promising IDO1 inhibitory activity as new cancer drug candidates: Derivatives of N,N'-diphenylurea linked with 1,2,3-triazole
    Sun, Bin
    Liu, Xiaofei
    Sun, Xiuwei
    Zhou, Yingjie
    Gong, Xiaoqing
    Mao, Longfei
    Shi, Weichen
    Deng, Peng
    Shi, Lin
    PHARMAZIE, 2023, 78 (1-4): : 2 - 5
  • [23] Coumarins: Old Compounds with Novel Promising Therapeutic Perspectives
    Riveiro, M. E.
    De Kimpe, N.
    Moglioni, A.
    Vazquez, R.
    Monczor, F.
    Shayo, C.
    Davio, C.
    CURRENT MEDICINAL CHEMISTRY, 2010, 17 (13) : 1325 - 1338
  • [24] The Structure-Antimicrobial Activity Relationships of a Promising Class of the Compounds Containing the N-Arylpiperazine Scaffold
    Malik, Ivan
    Csollei, Jozef
    Jampilek, Josef
    Stanzel, Lukas
    Zadrazilova, Iveta
    Hosek, Jan
    Pospisilova, Sarka
    Cizek, Alois
    Coffey, Aidan
    O'Mahony, Jim
    MOLECULES, 2016, 21 (10)
  • [25] Novel fluconazole derivatives with promising antifungal activity
    Chandrika, Nishad Thamban
    Shrestha, Sanjib K.
    Ngo, Huy X.
    Howard, Kaitlind C.
    Garneau-Tsodikova, Sylvie
    BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 26 (03) : 573 - 580
  • [26] Synthesis and Insecticidal Activity of Novel Trifluoromethylbenzimidazole Linked N-Phenylamide Compounds
    Shi, Jian-Jun
    Li, Wei-Wei
    Tan, Cheng-Xia
    Hu, Dong-Song
    Han, Liang
    Xu, Tian-Ming
    Liu, Xing-Hai
    POLYCYCLIC AROMATIC COMPOUNDS, 2024, 44 (09) : 6125 - 6135
  • [27] ANTIMYCOTIC SUBSTANCES .3. FUNGISTATIC ACTIVITY IN SERIES OF DEHYDRO-N-MANNICH-BASES
    KREUTZBERGER, A
    ARCHIV DER PHARMAZIE, 1975, 308 (12) : 950 - 954
  • [28] Pro-Apoptotic Activity of Bioactive Compounds from Seaweeds: Promising Sources for Developing Novel Anticancer Drugs
    Agena, Rosette
    de Jesus Cortes-Sanchez, Alejandro
    Hernandez-Sanchez, Humberto
    Jaramillo-Flores, Maria Eugenia
    MARINE DRUGS, 2023, 21 (03)
  • [29] Fungal Endophytes: A Promising Frontier for Discovery of Novel Bioactive Compounds
    Gakuubi, Martin Muthee
    Munusamy, Madhaiyan
    Liang, Zhao-Xun
    Ng, Siew Bee
    JOURNAL OF FUNGI, 2021, 7 (10)
  • [30] Novel tick glutathione transferase inhibitors as promising acaricidal compounds
    Ozelame, Katiussa Paula Cover
    Mattia, Marilia Meneghel Colla
    Silva, Lucas Andre Dedavid e
    Randall, Lia M.
    Corvo, Ileana
    Saporiti, Tatiana
    Seixas, Adriana
    Vaz Jr, Itabajara da Silva
    Alvarez, Guzman
    TICKS AND TICK-BORNE DISEASES, 2022, 13 (05)
12345