N-Benzylsalicylthioamides as novel compounds with promising antimycotic activity

被引：3
|
作者：
Petrlikova, Eva [1 ]
Waisser, Karel [1 ]
Buchta, Vladimir [2 ,3 ]
Jilek, Petr [3 ]
Vejsova, Marcela [3 ]
机构：
[1] Charles Univ Prague, Dept Inorgan & Organ Chem, Fac Pharm Hradec Kralove, Hradec Kralove 50003, Czech Republic
[2] Univ Hosp, Dept Clin Microbiol, Hradec Kralove 50005, Czech Republic
[3] Charles Univ Prague, Dept Biol & Med Sci, Fac Pharm Hradec Kralove, Hradec Kralove 50003, Czech Republic
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 15期
关键词：
N-Benzylsalicylthioamides; Antifungal activity; QSAR; Lipophilicity; FUNGAL-INFECTIONS; MYCOSES; HOST;
D O I：
10.1016/j.bmcl.2010.06.023
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The in vitro biological activity of N-benzylsalicylthioamides was evaluated against eight fungal strains by the broth microdilution method and the results were compared with those obtained with fluconazole. The compounds exhibited an in vitro antifungal activity against the fluconazole-susceptible as well as the fluconazole-resistant fungal strains. The biological activity was analyzed by quantitative structure-activity relationship (QSAR). (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4535 / 4538
页数：4
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