Detection of novel astroviruses in urban brown rats and previously known astroviruses in humans

被引:76
作者
Chu, Daniel K. W. [1 ,2 ]
Chin, Alex W. H. [1 ,2 ]
Smith, Gavin J. [1 ,2 ]
Chan, Kwok-Hung [1 ,2 ]
Guan, Yi [1 ,2 ]
Peiris, J. S. Malik [1 ,2 ,3 ]
Poon, Leo L. M. [1 ,2 ]
机构
[1] Univ Hong Kong, Dept Microbiol, State Key Lab Emerging Infect Dis, Hong Kong, Hong Kong, Peoples R China
[2] Univ Hong Kong, Res Ctr Infect & Immunol, Hong Kong, Hong Kong, Peoples R China
[3] HKU Pasteur Res Ctr, Hong Kong, Hong Kong, Peoples R China
基金
美国国家卫生研究院;
关键词
DIVERSE ASTROVIRUSES; BATS; RECOMBINATION; SEQUENCE; DIARRHEA;
D O I
10.1099/vir.0.022764-0
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Several novel astroviruses have been recently discovered in humans and in other animals. Here, we report results from our surveillance of astroviruses in human and rodent faecal samples in Hong Kong. Classical human astroviruses (n=9) and a human MLB1 astrovirus were detected in human faecal samples (n=622). Novel astroviruses were detected from 1.6% of the faecal samples of urban brown rat (Rattus norvegicus) (n=441), indicating the prevalence of astrovirus infection in rats might be much lower than that recently observed in bats These rat astroviruses were phylogenetically related to recently discovered human astroviruses MLB1 and MLB2, suggesting that the MLB viruses and these novel rat astroviruses may share a common ancestor.
引用
收藏
页码:2457 / 2462
页数:6
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