Grip strength is not associated with incident type 2 diabetes mellitus in healthy adults: The CoLaus study

Aims: We examined the association of grip strength with incident type 2 diabetes mellitus (T2DM) in healthy subjects initially aged 50 to 75 years after a follow-up of 5.5 years and 10.7 years. Methods: This was a prospective, population-based study derived from the CoLaus (Cohorte Lausannoise) study including 2318 participants (aged 60.2 y; 1354 women) free from T2DM at baseline. Grip strength was assessed using a handheld dynamometer. The effect of grip strength on the incidence of T2DM was analyzed by logistic regression. Results: After a follow-up of 5.5 years, 190 (8.2%) T2DM cases were identified. In bivariate analysis, participants who developed T2DM had a higher absolute grip strength (35.3 +/- 10.6 versus 33.2 +/- 10.7 kg, P = 0.013). Analysis between grip strength expressed in 5 kg increment and incident TD2M showed a negative association when adjusted for age and sex [ORs (95% CI): 0.88 (0.79, 0.98)], or for age, sex and body mass index (BMI) [ORs (95% CI): 0.87 (0.78, 097)]. After a follow-up of 10.7 years, 131 supplemental (7.3%) T2DM cases were identified, but there was no association between grip strength and incident T2DM in bivariate and multivariable analysis, potentially due to a lack of statistical power. Conclusions: In non elderly healthy adults, the risk of incident T2DM is overall not associated with grip strength over a maximum follow-up of 10.7 years. Future studies are warranted to better assess the association between grip strength and incident T2DM in bigger and even younger cohorts. (C) 2017 Elsevier B.V. All rights reserved.