PVT1 is a prognostic marker associated with immune invasion of bladder urothelial carcinoma

被引:1
作者
Li, Peiyuan [1 ]
Qiao, Gangjie [1 ]
Lu, Jian [2 ]
Ji, Wenbin [1 ]
Gao, Chao [1 ]
Qi, Feng [1 ]
机构
[1] Tianjin Med Univ Gen Hosp, Dept Gen Surg, 154 Anshan Rd, Tianjin 300052, Peoples R China
[2] Anhui Med Univ, Affiliated Hosp 1, Dept Gastroenterol, 218 Jixi Rd, Hefei 230022, Peoples R China
关键词
PVT1; bioinformatics; biomarker; bladder urothelial carcinoma; immune infiltration; INHIBITS TUMORIGENESIS; CANCER; EXPRESSION; ONCOGENE; KERATINS; GROWTH; CELLS; RNAS;
D O I
10.3934/mbe.2022009
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Plasmacytoma variant translocation 1 (PVT1) is involved in multiple signaling pathways and plays an important regulatory role in a variety of malignant tumors. However, its role in the prognosis and immune invasion of bladder urothelial carcinoma (BLCA) remains unclear. This study investigated the expression of PVT1 in tumor tissue and its relationship with immune invasion, and determined its prognostic role in patients with BLCA. Patients were identified from the cancer genome atlas (TCGA). The enrichment pathway and function of PVT1 were explained by gene ontology (GO) term analysis, gene set enrichment analysis (GSEA) and single-sample gene set enrichment analysis (ssGSEA), and the degree of immune cell infiltration was quantified. Kaplan-Meier analysis and Cox regression were used to analyze the correlation between PVT1 and survival rate. PVT1-high BLCA patients had a lower 10-year disease-specific survival (DSS P < 0.05) and overall survival (OS P < 0.05). Multivariate Cox regression analysis showed that PVT1 (high vs. low) (P = 0.004) was an independent prognostic factor. A nomogram was used to predict the effect of PVT1 on the prognosis. PVT1 plays an important role in the progression and prognosis of BLCA and can be used as a medium biomarker to predict survival after cystectomy.
引用
收藏
页码:169 / 190
页数:22
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