Synthesis and characterization of a tetracycline-platinum (II) complex active against resistant bacteria

被引：34

作者：

Chartone-Souza, E

Loyola, TL

Bucclarelli-Rodriguez, W

Menezes, MAD

Rey, NA

Pereira-Mala, EC ^{[1
]}

机构：

[1] Univ Fed Minas Gerais, ICEx, Dept Quim, BR-31270901 Belo Horizonte, MG, Brazil

[2] Univ Fed Minas Gerais, ICB, Dept Biol Geral, BR-31270901 Belo Horizonte, MG, Brazil

[3] CNEN, CDTN, BR-30123970 Belo Horizonte, MG, Brazil

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 2005年 / 99卷 / 05期

关键词：

synthesis; tetracycline-platinum complex; antimicrobial activity; bacterial resistance;

D O I：

10.1016/j.jinorgbio.2005.01.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A tetracycline-platinum(II) complex, [PtCl2(C22H24N2O8)], was synthesized and characterized by elemental analysis, conductivity and thermogravimetric analyses, and infrared spectroscopy. The interaction of tetracycline (Tc) with platinum(II) ions was also studied in aqueous solution by H-1 NMR and circular dichroism spectroscopies. Tetracycline forms a 1:1 complex with platinum via the oxygen of the hydroxyl group at the A ring and that of the amide group. The complex is as efficient as tetracycline in inhibiting the growth of two Escherichia coli sensitive bacterial strains and six times more potent against E coli HB101/pBR322, a bacterial strain resistant to tetracycline. This finding is very important because the use of tetracycline to treat bacterial infections has declined due to the emergence of resistant organisms. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：1001 / 1008

页数：8

共 36 条

[1] Synthesis and spectroscopic properties of anhydrotetracyclineplatinum(II)dichloride [J].