A New Monoterpenoid Glycoside from Myrica esculenta and the Inhibition of Angiotensin I-Converting Enzyme

被引：19

作者：

Nhiem, Nguyen Xuan ^{[1
,2
]}

Kiem, Phan Van ^{[2
]}

Minh, Chau Van ^{[2
]}

Tai, Bui Huu ^{[2
]}

Cuong, Nguyen Xuan ^{[2
]}

Thu, Vu Kim ^{[2
]}

Anh, Hoang Le Tuan ^{[2
]}

Jo, Sung-Hoon ^{[3
]}

Jang, Hae-Dong ^{[3
]}

Kwon, Young-In ^{[3
]}

Kim, Young Ho ^{[1
]}

机构：

[1] Chungnam Natl Univ, Coll Pharm, Taejon 305764, South Korea

[2] Vietnam Acad Sci & Technol, Inst Marine Biochem, Hanoi, Vietnam

[3] Hannam Univ, Dept Food & Nutr, Taejon 305811, South Korea

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2010年 / 58卷 / 10期

基金：

新加坡国家研究基金会;

关键词：

Myrica esculenta; myresculoside; angiotensin I-converting enzyme inhibitor; antihypertensive; BARK; TRITERPENOIDS; CONSTITUENTS;

D O I：

10.1248/cpb.58.1408

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

One new monoterpenoid glycoside, myresculoside (1), and eleven known compounds, were isolated from methanol extract of Myrica esculenta leaves by repeated column chromatography. The effects of these compounds on angiotensin I-converting enzyme (ACE) inhibition were investigated. Compounds 3 and 4 showed the most potent ACE inhibition with rates of 29.97% and 25.63% at concentration of 100 mu M, respectively. Compounds 5, 6, and 11 showed weak activity with inhibitory rates of 0.07-1.41% at concentration of 100 mu M.

引用

页码：1408 / 1410

页数：3

共 18 条

[1]

AGARWAL KP, 1963, INDIAN J CHEM, V1, P28

[2] Puqienine E: An angiotensin converting enzyme inhibitory steroidal alkaloid from Fritillaria puqiensis [J].

An, Jing-Jing ;

Zhou, Jian-Liang ;

Li, Hui-Jun ;

Jiang, Yan ;

Li, Ping .

FITOTERAPIA, 2010, 81 (03) :149-152

[3]

Bich D.H., 2004, MED PLANTS ANIMALS V, V1, P612

[4]

Ishikawa T, 1998, CHEM PHARM BULL, V46, P1738

[5]

JAYASINGHE L, 1993, PHYTOCHEMISTRY, V34, P1111, DOI 10.1016/S0031-9422(00)90726-X

[6] Bioactive triterpenoids from Callistemon lanceolatus [J].

Jeong, Wonsik ;

Hong, Seong Su ;

Kim, Nahyun ;

Yang, Young Taek ;

Shin, Yu Su ;

Lee, Chul ;

Hwang, Bang Yeon ;

Lee, Dongho .

ARCHIVES OF PHARMACAL RESEARCH, 2009, 32 (06) :845-849

[7]

Kitajima J, 1998, CHEM PHARM BULL, V46, P1595

[8]

Kwon YII, 2006, ASIA PAC J CLIN NUTR, V15, P107

[9] Angiotensin-converting, enzyme inhibitory activity of water-soluble extracts of Asiago d'allevo cheese [J].

Lignitto, Laura ;

Cavatorta, Valeria ;

Balzan, Stefania ;

Gabai, Gianfranco ;

Galaverna, Gianni ;

Novelli, Enrico ;

Sforza, Stefano ;

Segato, Severino .

INTERNATIONAL DAIRY JOURNAL, 2010, 20 (01) :11-17

[10] Anti-androgenic activity of Myricae Cortex -: Isolation of active constituents from bark of Myrica rubra [J].

Matsuda, H ;

Yamazaki, M ;

Matsuo, K ;

Asanuma, Y ;

Kubo, M .

BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2001, 24 (03) :259-263

← 1 2 →