Randomized, Phase II Dose Optimization Study of Chimeric Antigen Receptor Modified T Cells Directed Against CD19 (CTL019) in Patients with Relapsed, Refractory CLL

被引：0

作者：

Porter, David L. ^{[1
]}

Frey, Noelle V. ^{[2
]}

Melenhorst, J. Joseph ^{[3
]}

Hwang, Wei-Ting ^{[4
]}

Lacey, Simon F. ^{[1
]}

Shaw, Pamela ^{[5
]}

Chew, Anne ^{[5
]}

Grupp, Stephan A. ^{[1
,6
]}

Capobianchi, James ^{[5
]}

Gilmore, Joan ^{[1
]}

Kalos, Michael

Litchman, Manuel ^{[4
,7
]}

Lledo, Lester ^{[1
]}

Loren, Alison Wakoff ^{[1
]}

Mahnke, Yolanda ^{[1
]}

Marcucci, Katherine T. ^{[1
]}

McConville, Holly ^{[1
]}

Shen, Angela ^{[8
]}

Wood, Patricia A. ^{[8
]}

Zheng, Zhaohui ^{[1
]}

Levine, Bruce L. ^{[5
]}

June, Carl H. ^{[5
]}

机构：

[1] Univ Penn, Philadelphia, PA 19104 USA

[2] Univ Penn, Abramson Canc Ctr, Philadelphia, PA 19104 USA

[3] Univ Penn, Perelman Sch Med, Abramson Canc Ctr, Philadelphia, PA 19104 USA

[4] Univ Penn, Sch Med, Philadelphia, PA 19104 USA

[5] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA

[6] Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA

[7] Novartis, E Hanover, NJ USA

[8] Novartis Pharmaceut, E Hanover, NJ USA

来源：

BLOOD | 2014年 / 124卷 / 21期

关键词：

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页数：4

共 50 条

[1] Randomized, Phase II Dose Optimization Study Of Chimeric Antigen Receptor Modified T Cells Directed Against CD19 (CTL019) In Patients With Relapsed, Refractory CLL
Porter, David L.
Kalos, Michael
Frey, Noelle V.
Grupp, Stephan A.
Loren, Alison W.
Jemision, Christina
Gilmore, Joan
McConville, Holly
Capobianchi, James
Lledo, Lester
Chew, Anne
Shen, Angela
Wood, Patricia A.
Litchman, Manuel
Zheng, Zhaohui
Levine, Bruce L.
June, Carl H.
BLOOD, 2013, 122 (21)
[2] Phase IIa Trial of Chimeric Antigen Receptor Modified T Cells Directed Against CD19 (CTL019) in Patients with Relapsed or Refractory CD19+Lymphomas
Schuster, Stephen J.
Svoboda, Jakub
Nasta, Sunita Dwivedy
Porter, David L.
Chong, Elise A.
Mahnke, Yolanda
Lacey, Simon F.
Melenhorst, J. Joseph
Chew, Anne
Shah, Gaurav
Hasskarl, Jens
Litchman, Manuel
Wasik, Mariusz A.
Landsburg, Daniel J.
Mato, Anthony R.
Garfall, Alfred L.
Frey, Noelle V.
Marcucci, Katherine T.
Shea, Joanne
McConville, Holly
Zheng, Zhaohui
Levine, Bruce L.
June, Carl H.
BLOOD, 2014, 124 (21)
[3] Phase IIa trial of chimeric antigen receptor modified T cells directed against CD19 (CTL019) in patients with relapsed or refractory CD19+lymphomas.
Schuster, Stephen J.
Svoboda, Jakub
Nasta, Sunita
Porter, David L.
Mato, Anthony
Shah, Gaurav D.
Landsburg, Daniel Jeffrey
Chong, Elise A.
Lacey, Simon F.
Melenhorst, Jan J.
Chew, Anne
Hasskarl, Jens
Shah, Nirav Niranjan
Wasik, Mariusz A.
Marcucci, Katherine
Zheng, Zhaohui
Levine, Bruce
June, Carl H.
JOURNAL OF CLINICAL ONCOLOGY, 2015, 33 (15)
[4] CHIMERIC ANTIGEN RECEPTOR MODIFIED T CELLS DIRECTED AGAINST CD19 (CTL019) INDUCE CLINICAL RESPONSES IN PATIENTS WITH RELAPSED OR REFRACTORY CD19+LYMPHOMAS
Levine, B.
Svoboda, J.
Nasta, S. D.
Porter, D.
Chong, E.
Lacey, S.
Mahnke, Y.
Melenhorst, J.
Chew, A.
Shah, G.
Hasskar, J.
Wasik, M.
Landsburg, D.
Mato, A.
Garfall, A.
Frey, N.
Shaw, P.
Marcucci, K.
Shea, J.
McConville, H.
Manvar, N.
O'Rourke, M.
Lamontagne, A.
Bersenev, A.
Zheng, Z.
Schuster, S.
June, C.
CYTOTHERAPY, 2015, 17 (06) : S13 - S13
[5] Sustained Remissions Following Chimeric Antigen Receptor Modified T Cells Directed Against CD19 (CTL019) in Patients with Relapsed or Refractory CD19+Lymphomas
Schuster, Stephen J.
Svoboda, Jakub
Nasta, Sunita Dwivedy
Porter, David L.
Chong, Elise A.
Landsburg, Daniel J.
Mato, Anthony R.
Lacey, Simon F.
Melenhorst, Jan J.
Chew, Anne
Hasskarl, Jens
Shah, Gaurav D.
Wasik, Mariusz A.
Marcucci, Katherine T.
Zheng, Zhaohui
Levine, Bruce L.
June, Carl H.
BLOOD, 2015, 126 (23)
[6] Randomized, phase II dose optimization study of chimeric antigen receptor (CAR) modified T cells directed against CD19 in patients (pts) with relapsed, refractory (R/R) CLL
Porter, David L.
Frey, Noelle V.
Melenhorst, Jan J.
Hwang, Wei-Ting
Lacey, Simon F.
Shaw, Pamela A.
Chew, Anne
Marcucci, Katherine
Gill, Saar
Loren, Alison W.
Mato, Anthony R.
Schuster, Stephen J.
Lledo, Lester
McConville, Holly
Gilmore, Joan
Capobianchi, James
Kalos, Michael D.
Grupp, Stephan A.
Levine, Bruce
June, Carl H.
JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (15)
[7] Chimeric Antigen Receptor Modified T Cells Directed Against CD19 (CTL019) in Patients with Poor Prognosis, Relapsed or Refractory CD19+Follicular Lymphoma: Prolonged Remissions Relative to Antecedent Therapy
Chong, Elise A.
Svoboda, Jakub
Nasta, Sunita Dwivedy
Porter, David L.
Winchell, Nicole
Landsburg, Daniel J.
Mato, Anthony R.
Lacey, Simon F.
Melenhorst, Jan J.
Chew, Anne
Hasskarl, Jens
Marcucci, Katherine T.
Levine, Bruce L.
June, Carl H.
Schuster, Stephen J.
BLOOD, 2016, 128 (22)
[8] Cellular Kinetics of Chimeric Antigen Receptor T Cells (CTL019) in Patients with Relapsed/Refractory CD19+Leukemia
Mueller, Karen Thudium
Chakraborty, Abhijit
Wood, Patricia A.
Awasthi, Rakesh
Quintas-Cardama, Alfonso
Han, Xia
Maude, Shannon L.
Grupp, Stephan A.
Porter, David L.
Frey, Noelle
Marcucci, Katherine T.
Levine, Bruce L.
Melenhorst, Jan J.
June, Carl H.
Lacey, Simon F.
BLOOD, 2016, 128 (22)
[9] Recovery of humoral immunity in patients with durable complete responses following chimeric antigen receptor modified t cells directed against CD19 (CTL019).
Schuster, Stephen J.
Svoboda, Jakub
Nasta, Sunita
Chong, Elise A.
Porter, David L.
Landsburg, Daniel Jeffrey
Mato, Anthony R.
Bhoj, Vijay G.
Milone, Michael
Lacey, Simon F.
Strelec, Lauren E.
Zhou, Alice Y.
Melenhorst, Jan J.
Chew, Anne
Hasskarl, Jens
Wasik, Mariusz A.
Marcucci, Katherine
Zheng, Zhaohui
Levine, Bruce
June, Carl H.
JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (15)
[10] Durable Remissions in Children with Relapsed/Refractory ALL Treated with T Cells Engineered with a CD19-Targeted Chimeric Antigen Receptor (CTL019)
Grupp, Stephan A.
Maude, Shannon L.
Shaw, Pamela A.
Aplenc, Richard
Barrett, David M.
Callahan, Colleen
Lacey, Simon F.
Levine, Bruce L.
Melenhorst, J. Joseph
Motley, Laura
Rheingold, Susan R.
Teachey, David T.
Wood, Patricia A.
Porter, David
June, Carl H.
BLOOD, 2015, 126 (23)

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