Prognostic index for survival in patients after treatment for primary hepatocellular carcinoma

被引:8
作者
Kogo, Mari
Kano, Ayuko
Kiuchi, Yuji
Mitamura, Keiji
Yoneyama, Keiichiro
机构
[1] Showa Univ, Sch Pharmaceut Sci, Dept Pathophysiol, Shinagawa Ku, Tokyo 1428555, Japan
[2] Showa Univ, Sch Med, Dept Internal Med 2, Tokyo 142, Japan
[3] Showa Univ, Hlth Serv Ctr, Tokyo, Japan
关键词
hepatocellular carcinoma; transcatheter arterial embolization; percutaneous ethanol injection; multivariate analysis; prognostic index;
D O I
10.1007/s10620-006-9137-x
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
We retrospectively evaluated clinical factors affecting long-term survival after treatment for hepatocellular carcinoma (HCC) to predict the reliability of the prognosis of patients with HCC. We analyzed 157 patients who received treatment for HCC. The prognostic index (PI) was evaluated using the Cox regression model. The overall cumulative survival rates were 79.7% at 1 year, 51.1% at 3 years, and 24.9% at 5 years. The PI was calculated by the following formula, consisting of five factors: PI=0.637xnumber of tumor lesions+0.103xtumor diameter+1.003xascites+0.915xportal vein tumor thrombosis - 0.006xcholinesterase+2.0. It was found that liver function and progression of the tumor are the most important factors for prognosis after treatment for HCC. The PI, based on five factors, will in future be an appropriate index to predict the prognosis of patients with HCC.
引用
收藏
页码:2444 / 2451
页数:8
相关论文
共 33 条
[1]  
Ajiki W, 2002, JPN J CLIN ONCOL, V32, P318
[2]  
AKASHI Y, 1991, HEPATOLOGY, V14, P262, DOI 10.1002/hep.1840140210
[3]   Transarterial chemoembolization for unresectable hepatocellular carcinoma:: Meta-analysis of randomized controlled trials [J].
Cammà, C ;
Schepis, F ;
Orlando, A ;
Albanese, M ;
Shahied, L ;
Trevisani, F ;
Andreone, P ;
Craxì, A ;
Cottone, M .
RADIOLOGY, 2002, 224 (01) :47-54
[4]   MULTIVARIATE SURVIVAL ANALYSIS USING COX REGRESSION-MODEL [J].
CHRISTENSEN, E .
HEPATOLOGY, 1987, 7 (06) :1346-1358
[5]  
COX DR, 1972, J R STAT SOC B, V34, P187
[6]   Hepatitis C virus related cirrhosis: time to occurrence of hepatocellular carcinoma and death [J].
Degos, F ;
Christidis, C ;
Ganne-Carrie, N ;
Farmachidi, JP ;
Degott, C ;
Guettier, C ;
Trinchet, JC ;
Beaugrand, M ;
Chevret, S .
GUT, 2000, 47 (01) :131-136
[7]  
Hanazaki K, 2001, AM J GASTROENTEROL, V96, P1243, DOI 10.1111/j.1572-0241.2001.03634.x
[8]   Natural history of hepatitis B and C virus infections [J].
Iino, S .
ONCOLOGY, 2002, 62 :18-23
[9]  
IKEDA K, 1991, CANCER, V68, P2150, DOI 10.1002/1097-0142(19911115)68:10<2150::AID-CNCR2820681011>3.0.CO
[10]  
2-F