Deficiency of TLR4 ameliorates hypoperfusion-induced brain pathology

被引：11
作者：
Liu, Yang [1 ,2 ,3 ]
Fassbender, Klaus [1 ,2 ]
机构：
[1] Saarland Univ, Dept Neurol, Kirrberger Str, D-66421 Homburg, Germany
[2] Saarland Univ, German Inst Dementia Prevent DIDP, D-66421 Homburg, Germany
[3] Tongji Univ, Sch Med, Tongji Hosp, Dept Clin Lab, Shanghai 200065, Peoples R China
来源：
THERANOSTICS | 2018年 / 8卷 / 22期
基金：
中国国家自然科学基金;
关键词：
chronic cerebral hypoperfusion; microglia; inflammation; autophagy; TLR4; ACTIVATION; DISEASE;
D O I：
10.7150/thno.30953
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Microglial inflammatory activation contributes to chronic cerebral hypoperfusion-induced brain pathology. This editorial highlights a study by Qin et al. (Theranostics 2018; 8(19): 5434-5451. doi:10.7150/thno.27882) that deficiency of TLR4 attenuates cognitive dysfunction and white matter injury by reducing autophagy and pro-inflammatory activation in microglia.
引用
收藏
页码：6355 / 6356
页数：2
相关论文
共 12 条
[1]   Dimethyl fumarate improves white matter function following severe hypoperfusion: Involvement of microglia/macrophages and inflammatory mediators [J].
Fowler, Jill H. ;
McQueen, Jamie ;
Holland, Philip R. ;
Manso, Yasmina ;
Marangoni, Martina ;
Scott, Fiona ;
Chisholm, Emma ;
Scannevin, Robert H. ;
Hardingham, Giles E. ;
Horsburgh, Karen .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2018, 38 (08) :1354-1370
[2]   Myeloid differentiation factor 88-deficient bone marrow cells improve Alzheimer's disease-related symptoms and pathology [J].
Hao, Wenlin ;
Liu, Yang ;
Liu, Shirong ;
Walter, Silke ;
Grimm, Marcus O. ;
Kiliaan, Amanda J. ;
Penke, Botond ;
Hartmann, Tobias ;
Ruebe, Claudia E. ;
Menger, Michael D. ;
Fassbender, Klaus .
BRAIN, 2011, 134 :278-292
[3]   Cerebrovascular disease in ageing and Alzheimer's disease [J].
Love, Seth ;
Miners, J. Scott .
ACTA NEUROPATHOLOGICA, 2016, 131 (05) :645-658
[4]   TRPM2 Channel Aggravates CNS Inflammation and Cognitive Impairment via Activation of Microglia in Chronic Cerebral Hypoperfusion [J].
Miyanohara, Jun ;
Kakae, Masashi ;
Nagayasu, Kazuki ;
Nakagawa, Takayuki ;
Mori, Yasuo ;
Arai, Ken ;
Shirakawa, Hisashi ;
Kaneko, Shuji .
JOURNAL OF NEUROSCIENCE, 2018, 38 (14) :3520-3533
[5]   Microglial TLR4-dependent autophagy induces ischemic white matter damage via STAT1/6 pathway [J].
Qin, Chuan ;
Liu, Qian ;
Hu, Zi-Wei ;
Zhou, Luo-Qi ;
Shang, Ke ;
Bosco, Dale B. ;
Wu, Long-Jun ;
Tian, Dai-Shi ;
Wang, Wei .
THERANOSTICS, 2018, 8 (19) :5434-5451
[6]   Toll-like receptors modulate adult hippocampal neurogenesis [J].
Rolls, Asya ;
Shechter, Ravid ;
London, Anat ;
Ziv, Yaniv ;
Ronen, Ayal ;
Levy, Rinat ;
Schwartz, Michal .
NATURE CELL BIOLOGY, 2007, 9 (09) :1081-U61
[7]   Subcortical ischaemic vascular dementia [J].
Román, GC ;
Erkinjuntti, T ;
Wallin, A ;
Pantoni, L ;
Chui, HC .
LANCET NEUROLOGY, 2002, 1 (07) :426-436
[8]   Postnatal activation of TLR4 in astrocytes promotes excitatory synaptogenesis in hippocampal neurons [J].
Shen, Yi ;
Qin, Huaping ;
Chen, Juan ;
Mou, Lingyan ;
He, Yang ;
Yan, Yixiu ;
Zhou, Hang ;
Lv, Ya ;
Chen, Zhong ;
Wang, Junlu ;
Zhou, Yu-Dong .
JOURNAL OF CELL BIOLOGY, 2016, 215 (05) :719-734
[9]   White matter lesions and glial activation in a novel mouse model of chronic cerebral hypoperfusion [J].
Shibata, M ;
Ohtani, R ;
Ihara, M ;
Tomimoto, H .
STROKE, 2004, 35 (11) :2598-2603
[10]   Endothelial TLR4 and the microbiome drive cerebral cavernous malformations [J].
Tang, Alan T. ;
Hoi, Jaesung P. C. ;
Kotzin, Jonathan J. ;
Yang, Yiqing ;
Hong, Courtney C. ;
Hobson, Nicholas ;
Girard, Romuald ;
Zeineddine, Hussein A. ;
Lightle, Rhonda ;
Moore, Thomas ;
Cao, Ying ;
Shenkar, Robert ;
Chen, Mei ;
Mericko, Patricia ;
Yang, Jisheng ;
Li, Li ;
Tanes, Ceylan ;
Kobuley, Dmytro ;
Vosa, Urmo ;
Whitehead, Kevin J. ;
Li, Dean Y. ;
Franke, Lude ;
Hart, Blaine ;
Schwaninger, Markus ;
Henao-Mejia, Jorge ;
Morrison, Leslie ;
Kim, Helen ;
Awad, Issam A. ;
Zheng, Xiangjian ;
Kahn, Mark L. .
NATURE, 2017, 545 (7654) :305-+
12