Therapeutic implications of chemokine-mediated pathways in atherosclerosis: realistic perspectives and utopias

被引：11

作者：

Apostolakis, Stavros ^{[1
]}

Amanatidou, Virginia ^{[1
]}

Spandidos, Demetrios A. ^{[1
]}

机构：

[1] Univ Crete, Fac Med, Dept Clin Virol, Iraklion, Greece

来源：

ACTA PHARMACOLOGICA SINICA | 2010年 / 31卷 / 09期

关键词：

chemokines; chemokine receptors; atherosclerosis; therapeutic potential; MONOCYTE CHEMOATTRACTANT PROTEIN-1; SMOOTH-MUSCLE-CELLS; RECEPTOR-DEFICIENT MICE; E-KNOCKOUT MICE; APOLIPOPROTEIN-E; CARDIOVASCULAR-DISEASE; LESION FORMATION; LEUKOCYTE RECRUITMENT; RHEUMATOID-ARTHRITIS; ATHEROMATOUS PLAQUES;

D O I：

10.1038/aps.2010.131

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Current perspectives on the pathogenesis of atherosclerosis strongly support the involvement of inflammatory mediators in the establishment and progression of atherosclerostic lesions. Chemokine-mediated mechanisms are potent regulators of such processes by orchestrating the interactions of inflammatory cellular components of the peripheral blood with cellular components of the arterial wall. The increasing evidence supporting the role of chemokine pathways in atherosclerosis renders chemokine ligands and their receptors potential therapeutic targets. In the following review, we aim to highlight the special structural and functional features of chemokines and their receptors in respect to their roles in atherosclerosis, and examine to what extent available data can be applied in disease management practices.

引用

页码：1103 / 1110

页数：8

共 66 条

[1] Monocyte chemoattractant protein-1 accelerates atherosclerosis in apolipoprotein E-deficient mice [J].

Aiello, RJ ;

Bourassa, PAK ;

Lindsey, S ;

Weng, WF ;

Natoli, E ;

Rollins, BJ ;

Milos, PM .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1999, 19 (06) :1518-1525

[2]

Apostolakis S, 2006, INT J MOL MED, V17, P691

[3] CX3CR1 receptor is up-regulated in monocytes of coronary artery diseased patients: Impact of pre-inflammatory stimuli and renin-angiotensin system modulators [J].

Apostolakis, Stavros ;

Krambovitis, Elias ;

Vlata, Zaharenia ;

Kochiadakis, Georgios E. ;

Baritaki, Stavroula ;

Spandidos, Demetrios A. .

THROMBOSIS RESEARCH, 2007, 121 (03) :387-395

[4] Interleukin 8 and cardiovascular disease [J].

Apostolakis, Stavros ;

Vogiatzi, Konstantina ;

Amanatidou, Virginia ;

Spandidos, Demetrios A. .

CARDIOVASCULAR RESEARCH, 2009, 84 (03) :353-360

[5] Interleukin-8 production by macrophages from atheromatous plaques [J].

Apostolopoulos, J ;

Davenport, P ;

Tipping, PG .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1996, 16 (08) :1007-1012

[6] Chemokine regulation of atherosclerosis [J].

Barlic, Jana ;

Murphy, Philip M. .

JOURNAL OF LEUKOCYTE BIOLOGY, 2007, 82 (02) :226-236

[7] Atherogenic lipids induce adhesion of human coronary artery smooth muscle cells to macrophages by up-regulating chemokine CX3CL1 on smooth muscle cells in a TNFα-NFκB-dependent manner [J].

Barlic, Jana ;

Zhang, Yuan ;

Murphy, Philip M. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (26) :19167-19176

[8] A leukocyte homologue of the IL-8 receptor CXCR-2 mediates the accumulation of macrophages in atherosclerotic lesions of LDL receptor-deficient mice [J].

Boisvert, WA ;

Santiago, R ;

Curtiss, LK ;

Terkeltaub, RA .

JOURNAL OF CLINICAL INVESTIGATION, 1998, 101 (02) :353-363

[9] Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosis [J].

Boring, L ;

Gosling, J ;

Cleary, M ;

Charo, IF .

NATURE, 1998, 394 (6696) :894-897

[10] Inhibition of interleukin-8 blocks myocardial ischemia-reperfusion injury [J].

Boyle, EM ;

Kovacich, JC ;

Hèbert, CA ;

Canty, TG ;

Chi, E ;

Morgan, EN ;

Pohlman, TH ;

Verrier, ED .

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 1998, 116 (01) :114-120

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