PRIMARY ADRENAL LYMPHOMA: A SINGLE-CENTER EXPERIENCE

被引:14
作者
Kasaliwal, Rajeev [1 ]
Goroshi, Manjunath [1 ]
Khadilkar, Kranti [1 ]
Bakshi, Ganesh [2 ]
Rangarajan, Venkatesh [2 ]
Malhotra, Gaurav [3 ]
Lila, Anurag [1 ]
Bandgar, Tushar [1 ]
Shah, Nalini S. [1 ]
机构
[1] King Edward Mem Hosp, Dept Endocrinol, Bombay 400012, Maharashtra, India
[2] Tata Mem Hosp, Bombay 400012, Maharashtra, India
[3] Radiat Med Ctr, Bombay, Maharashtra, India
关键词
OF-THE-LITERATURE; NON-HODGKINS-LYMPHOMA; B-CELL LYMPHOMA; F-18-FDG PET/CT; CHEMOTHERAPY; INVOLVEMENT; SURVIVAL; DISEASE; ORIGIN;
D O I
10.4158/EP14471.OR
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: To describe the clinical presentation, biochemistry, imaging features, and treatment outcome of patients with primary adrenal lymphoma (PAL) presenting to a single tertiary care center. Methods: We performed a retrospective analysis of case records of 7 patients diagnosed with PAL between January 2011 and May 2014 at our institution in Mumbai, India. Results: Median age of presentation in our series was 48 years (range, 41 to 60 years), with a male to female ratio of 6:1. Bilateral adrenal involvement was seen in 4 of 7 patients (58%). Adrenal insufficiency (AI) was seen in 3 of the 4 patients with bilateral involvement (75%). Computed tomography showed slight to moderate contrast enhancement of adrenal masses in 4 of 5 patients (80%). Diffuse, large, B-cell lymphoma (DLBCL) was the most common immunophenotype (85%). One patient died due to rapid disease progression even before starting chemotherapy. Six patients were treated with chemotherapy and/or external beam radiotherapy. After 1 year, 2 more patients had died, whereas 4 patients were in remission. Conclusion: PAL should always be considered in differential diagnosis of bilateral adrenal mass with AI. DLBCL is the most common histologic subtype of PAL. Despite treatment, long-term prognosis of PAL remains poor.
引用
收藏
页码:719 / 724
页数:6
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