Autologous Stem Cell Mobilization and Collection

被引：20

作者：

Hsu, Yen-Michael S. ^{[1
]}

Cushing, Melissa M. ^{[2
]}

机构：

[1] Weill Cornell Med Coll, Pathol & Lab Med Transfus Med & Cellular Therapy, 525 East 68th St,Box 251, New York, NY 10065 USA

[2] Weill Cornell Med Coll, Transfus Med & Cellular Therapy, 525 East 68th St,Box 251,M09, New York, NY 10065 USA

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2016年 / 30卷 / 03期

关键词：

G-CSF; Plerixafor; Mobilization; Collection; Transplantation; Stem cell; Hematopoiesis; Laboratory; COLONY-STIMULATING FACTOR; HEMATOPOIETIC PROGENITOR-CELL; MULTIPLE-MYELOMA EFFECTIVENESS; NON-HODGKINS-LYMPHOMA; BONE-MARROW NICHE; PERIPHERAL-BLOOD; G-CSF; CANCER-PATIENTS; LARGE-VOLUME; COMPARING FILGRASTIM;

D O I：

10.1016/j.hoc.2016.01.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Peripheral blood stem cell collection is an effective approach to obtain a hematopoietic graft for stem cell transplantation. Developing hematopoietic stem/progenitor cell (HSPC) mobilization methods and collection algorithms have improved efficiency, clinical outcomes, and cost effectiveness. Differences in mobilization mechanisms may change the HSPC content harvested and result in different engraftment kinetics and complications. Patient-specific factors can affect mobilization. Incorporating these factors in collection algorithms and improving assays for evaluating mobilization further extend the ability to obtain sufficient HSPCs for hematopoietic repopulation. Technological advance and innovations in leukapheresis have improved collection efficiency and reduced adverse effects.

引用

页码：573 / +

页数：18

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