Characteristic Features of Protein Interaction with Single- and Double-Stranded RNA

被引:2
|
作者
Nikulin, Alexey D. [1 ]
机构
[1] Russian Acad Sci, Inst Prot Res, Pushchino 142290, Moscow Region, Russia
关键词
RNA-protein interaction; single-stranded RNA; double-stranded RNA; RNP domain; ribosomal proteins; PRE-RIBOSOMAL-RNA; RPSO MESSENGER-RNA; ESCHERICHIA-COLI; CRYSTAL-STRUCTURE; STRUCTURAL BASIS; BINDING DOMAINS; TRANSCRIPTION FACTOR; TRANSLATIONAL REGULATION; ANGSTROM RESOLUTION; RECOGNITION MOTIFS;
D O I
10.1134/S0006297921080125
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The review discusses differences between the specific protein interactions with single- and double-stranded RNA molecules using the data on the structure of RNA-protein complexes. Proteins interacting with the single-stranded RNAs form contacts with RNA bases, which ensures recognition of specific nucleotide sequences. Formation of such contacts with the double-stranded RNAs is hindered, so that the proteins recognize unique conformations of the RNA spatial structure and interact mainly with the RNA sugar-phosphate backbone.
引用
收藏
页码:1025 / 1040
页数:16
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