Myocarditis after COVID-19 mRNA vaccination: clinical observations and potential mechanisms

被引：194

作者：

Heymans, Stephane ^{[1
]}

Cooper, Leslie T. ^{[2
]}

机构：

[1] Maastricht Univ, Med Ctr, Cardiovasc Res Inst Maastricht, Maastricht, Netherlands

[2] Mayo Clin Florida, Dept Cardiovasc Med, Jacksonville, FL USA

来源：

NATURE REVIEWS CARDIOLOGY | 2022年 / 19卷 / 02期

关键词：

D O I：

10.1038/s41569-021-00662-w

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The risk of acute myocarditis associated with COVID-19 mRNA vaccination has garnered intense (social) media attention. However, myocarditis after COVID-19 mRNA vaccination is rare and usually resolves within days or weeks. Moreover, the risks of hospitalization and death associated with COVID-19 are greater than the risk associated with COVID-19 vaccination. Therefore, COVID-19 vaccination should be recommended in adolescents and adults.

引用

页码：75 / 77

页数：3

共 10 条

[1] Myocardial injury characterized by elevated cardiac troponin and in-hospital mortality of COVID-19: An insight from a meta-analysis [J].

Aikawa, Tadao ;

Takagi, Hisato ;

Ishikawa, Kiyotake ;

Kuno, Toshiki .

JOURNAL OF MEDICAL VIROLOGY, 2021, 93 (01) :51-55

[2] Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine [J].

Baden, Lindsey R. ;

El Sahly, Hana M. ;

Essink, Brandon ;

Kotloff, Karen ;

Frey, Sharon ;

Novak, Rick ;

Diemert, David ;

Spector, Stephen A. ;

Rouphael, Nadine ;

Creech, C. Buddy ;

McGettigan, John ;

Khetan, Shishir ;

Segall, Nathan ;

Solis, Joel ;

Brosz, Adam ;

Fierro, Carlos ;

Schwartz, Howard ;

Neuzil, Kathleen ;

Corey, Larry ;

Gilbert, Peter ;

Janes, Holly ;

Follmann, Dean ;

Marovich, Mary ;

Mascola, John ;

Polakowski, Laura ;

Ledgerwood, Julie ;

Graham, Barney S. ;

Bennett, Hamilton ;

Pajon, Rolando ;

Knightly, Conor ;

Leav, Brett ;

Deng, Weiping ;

Zhou, Honghong ;

Han, Shu ;

Ivarsson, Melanie ;

Miller, Jacqueline ;

Zaks, Tal .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 384 (05) :403-416

[3] Predictors of Mortality in Patients With Biopsy-Proven Viral Myocarditis: 10-Year Outcome Data [J].

Greulich, Simon ;

Seitz, Andreas ;

Mueller, Karin A. L. ;

Gruen, Stefan ;

Ong, Peter ;

Ebadi, Nawid ;

Kreisselmeier, Klaus Peter ;

Seizer, Peter ;

Bekeredjian, Raffi ;

Zwadlo, Carolin ;

Graeni, Christoph ;

Klingel, Karin ;

Gawaz, Meinrad ;

Sechtem, Udo ;

Mahrholdt, Heiko .

JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2020, 9 (16)

[4] The Quest for New Approaches in Myocarditis and Inflammatory Cardiomyopathy [J].

Heymans, Stephane ;

Eriksson, Urs ;

Lehtonen, Jukka ;

Cooper, Leslie T., Jr. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2016, 68 (21) :2348-2364

[5] Surveillance for Adverse Events After COVID-19 mRNA Vaccination [J].

Klein, Nicola P. ;

Lewis, Ned ;

Goddard, Kristin ;

Fireman, Bruce ;

Zerbo, Ousseny ;

Hanson, Kayla E. ;

Donahue, James G. ;

Kharbanda, Elyse O. ;

Naleway, Allison ;

Nelson, Jennifer Clark ;

Xu, Stan ;

Yih, W. Katherine ;

Glanz, Jason M. ;

Williams, Joshua T. B. ;

Hambidge, Simon J. ;

Lewin, Bruno J. ;

Shimabukuro, Tom T. ;

DeStefano, Frank ;

Weintraub, Eric S. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2021, 326 (14) :1390-1399

[6] Myocardial Pathology in COVID-19-Associated Cardiac Injury: A Systematic Review [J].

Maiese, Aniello ;

Frati, Paola ;

Del Duca, Fabio ;

Santoro, Paola ;

Manetti, Alice Chiara ;

La Russa, Raffaele ;

Di Paolo, Marco ;

Turillazzi, Emanuela ;

Fineschi, Vittorio .

DIAGNOSTICS, 2021, 11 (09)

[7] Myocarditis after BNT162b2 mRNA Vaccine against Covid-19 in Israel [J].

Mevorach, D. ;

Anis, E. ;

Cedar, N. ;

Bromberg, M. ;

Haas, E. J. ;

Nadir, E. ;

Olsha-Castell, S. ;

Arad, D. ;

Hasin, T. ;

Levi, N. ;

Asleh, R. ;

Amir, O. ;

Meir, K. ;

Cohen, D. ;

Dichtiar, R. ;

Novick, D. ;

Hershkovitz, Y. ;

Dagan, R. ;

Leitersdorf, I ;

Ben-Ami, R. ;

Miskin, I ;

Saliba, W. ;

Muhsen, K. ;

Levi, Y. ;

Green, M. S. ;

Keinan-Boker, L. ;

Alroy-Preis, S. .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 385 (23) :2140-2149

[8] Myocarditis Following Immunization With mRNA COVID-19 Vaccines in Members of the US Military [J].

Montgomery, Jay ;

Ryan, Margaret ;

Engler, Renata ;

Hoffman, Donna ;

McClenathan, Bruce ;

Collins, Limone ;

Loran, David ;

Hrncir, David ;

Herring, Kelsie ;

Platzer, Michael ;

Adams, Nehkonti ;

Sanou, Aliye ;

Cooper, Leslie T., Jr. .

JAMA CARDIOLOGY, 2021, 6 (10) :1202-1206

[9] Potential antigenic cross-reactivity between SARS-CoV-2 and human tissue with a possible link to an increase in autoimmune diseases [J].

Vojdani, Aristo ;

Kharrazian, Datis .

CLINICAL IMMUNOLOGY, 2020, 217

[10] Myocarditis after Covid-19 Vaccination in a Large Health Care Organization [J].

Witberg, Guy ;

Barda, Noam ;

Hoss, Sara ;

Richter, Ilan ;

Wiessman, Maya ;

Aviv, Yaron ;

Grinberg, Tzlil ;

Auster, Oren ;

Dagan, Noa ;

Balicer, Ran D. ;

Kornowski, Ran .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 385 (23) :2132-2139

← 1 →