Suppression of murine experimental autoimmune encephalomyelitis development by 1,25-dihydroxyvitamin D3 with autophagy modulation

被引：22
作者：
Zhen, Chao [1 ]
Feng, Xuedan [1 ]
Li, Zhe [2 ]
Wang, Yabo [3 ]
Li, Bin [1 ,4 ]
Li, Lin [1 ]
Quan, Moyuan [1 ]
Wang, Gaoning [1 ]
Guo, Li [1 ,4 ]
机构：
[1] Hebei Med Univ, Hosp 2, Dept Neurol, Shijiazhuang 050000, Hebei, Peoples R China
[2] Hebei Gen Hosp, Dept Neurol, Shijiazhuang 050051, Hebei, Peoples R China
[3] Hebei Med Univ, Hosp 3, Dept Orthopaed Surg, Shijiazhuang 050051, Hebei, Peoples R China
[4] Key Lab Hebei Neurol, Shijiazhuang 050000, Hebei, Peoples R China
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2015年 / 280卷
关键词：
1,25(OH)(2)D-3; Experimental autoimmune encephalomyelitis; Multiple sclerosis; Autophagy; Apoptosis; VITAMIN-D3 INDUCES AUTOPHAGY; MULTIPLE-SCLEROSIS; INHIBITION; INDUCTION; ATROPHY; MICE; LC3; MACROAUTOPHAGY; DEMYELINATION; PATHOGENESIS;
D O I：
10.1016/j.jneuroim.2015.01.012
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Multiple sclerosis (MS) has been associated with a history of sub-optimal exposure to ultraviolet light, implicating vitamin D3 as a possible protective agent. We evaluated whether 1,25(OH)(2)D-3 attenuates the progression of experimental autoimmune encephalomyelitis (EAE), and explored its potential mechanisms. EAE was induced in C57BL/6 mice via immunization with MOG(35-55). and some mice received 1,25(OH)(2)D-3. 1,25(OH)(2)D-3 inhibited EAE progression. Additionally, 1,25(OH)(2)D-3 reduced inflammation, demyelination, and neuron loss in the spinal cord. The protective effect of 1,25(OH)(2)D-3 was associated with significantly elevated expression of Beclin1, increased Bcl-2/Bax ratio, and decreased LC3-II accumulation. Thus, 1,25(OH)(2)D-3 may represent a promising new MS treatment. (C) 2015 Elsevier B.V. All rights reserved.
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页码：1 / 7
页数：7
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