Novel variants of infectious bursal disease virus can severely damage the bursa of fabricius of immunized chickens

被引：66

作者：

Fan, Linjin ^{[1
,2
]}

Wu, Tiantian ^{[1
,2
]}

Wang, Yulong ^{[1
,2
]}

Hussain, Altaf ^{[1
,2
]}

Jiang, Nan ^{[1
,2
]}

Gao, Li ^{[1
,2
]}

Li, Kai ^{[1
]}

Gao, Yulong ^{[1
,2
]}

Liu, Changjun ^{[1
]}

Cui, Hongyu ^{[1
]}

Pan, Qing ^{[1
]}

Zhang, Yanping ^{[1
]}

Wang, Xiaomei ^{[1
,2
,3
]}

Qi, Xiaole ^{[1
,2
]}

机构：

[1] Chinese Acad Agr Sci, Harbin Vet Res Inst, Div Avian Infect Dis, State Key Lab Vet Biotechnol, 678 Haping Rd, Harbin 150069, Heilongjiang, Peoples R China

[2] OIE Reference Lab Infect Bursal Dis, Harbin 150069, Peoples R China

[3] Jiangsu Coinnovat Ctr Prevent & Control Important, Yangzhou 225009, Jiangsu, Peoples R China

来源：

VETERINARY MICROBIOLOGY | 2020年 / 240卷

基金：

中国国家自然科学基金;

关键词：

Novel variant infectious bursal disease virus; Immunoprotection; Antigenic variation; ANTIGENIC VARIATION; CRYSTAL-STRUCTURE; GENOME SEGMENTS; VIRULENT; VP2; SUBSTITUTION; REPLICATION; CONTRIBUTE; CHALLENGE; REVEALS;

D O I：

10.1016/j.vetmic.2019.108507

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In recent years, atypical infectious bursal disease (IBD) with severe immunosuppression has brought new threats to the poultry industry and has caused considerable economic losses. Novel variant infectious bursal disease virus (IBDV) has been identified as the etiological pathogen and for unknown reasons is widespread in poultry on many chicken farms in China that have been immunized with vaccines against very virulent IBDV (vvIBDV). Using immunoprotection experiments in specific-pathogen-free chickens, we first verified that novel variant IBDV could severely damage the bursa of Fabricius of the important immune organ of immunized chicken in the presence of antibodies induced by three types of vvIBDV vaccines, which is a primary reason for the current epidemic of atypical IBD. Monoclonal antibody reactivity patterns and cross-neutralization assays further confirmed the obvious antigenic mismatch between novel variant IBDV and vvIBDV. Sequence analysis of the genome of novel variant IBDV (SHG19 strain) was performed and the key amino acid residues that might be involved in antigenicity and virulence differences of novel variant IBDV compared to vvIBDV were further analyzed. This study not only determined the primary reason for the atypical IBD epidemic, but also remind us of the urgency for developing new vaccines against novel variant IBDV.

引用

页数：7

共 46 条

[1]

Amini K, 2015, CAN J VET RES, V79, P261

[2]

[Anonymous], AGR SCI TECHNOL

[3]

[Anonymous], AGR SCI TECHNOL

[4] PERSISTENT ANTIGENIC VARIATION OF INFLUENZA A VIRUSES AFTER INCOMPLETE NEUTRALIZATION IN OVO WITH HETEROLOGOUS IMMUNE SERUM [J].