Obesity, inflammation and insulin resistance: Which role for adipokines?

被引：25
作者：
Antuna-Puente, Barbara
Feve, Bruno
Fellahi, Soraya
Bastard, Jean-Philippe
机构：
[1] Hop Tenon, AP HP, Serv Biochim & Hormonol, F-75970 Paris 20, France
[2] Univ Paris 06, Fac Med St Antoine, INSERM, U680, Paris, France
[3] CHU Bicetre, Serv Endocrinol, Le Kremlin Bicetre, France
[4] Univ Paris 11, INSERM, U693, Le Kremlin Bicetre, France
来源：
THERAPIE | 2007年 / 62卷 / 04期
关键词：
adipocyte; macrophage; obesity; diabetes; adipokines;
D O I：
10.2515/therapie:2007055
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Obesity, Inflammation and Insulin Resistance: Which Role for Adipokines? Adipose tissue is now recognized as an endocrine organ involved in regulating physiologic and pathologic processes including inflammation. It synthesizes and secretes hormones such as leptin and adiponectin. It can secrete other products namely adipokines including cytokines and chemokines. The release of adipokines by either adipocytes or adipose tissue-infiltrated macrophages leads to a chronic sub-inflammatory state that likely plays a major role in cardiovascular complications linked to obesity and insulin resistance.
引用
收藏
页码：285 / 292
页数：8
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