Cyclotheonamides E2 and E3, new potent serine protease inhibitors from the marine sponge of the genus Theonella

被引：42

作者：

Nakao, Y ^{[1
]}

Oku, N ^{[1
]}

Matsunaga, S ^{[1
]}

Fusetani, N ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Agr & Life Sci, Lab Aquat Nat Prod Chem, Bunkyo Ku, Tokyo 1138657, Japan

来源：

JOURNAL OF NATURAL PRODUCTS | 1998年 / 61卷 / 05期

关键词：

D O I：

10.1021/np970544n

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new potent serine protease inhibitors, cyclotheonamides E2 (3) and E3 (4), have been isolated from a marine sponge of the genus Theonella. Their structures were determined by interpretation of spectral data and chemical degradation studies. They are closely related to the previously reported cyclotheonamide E, from which they differ in the N-acyl group of the alanyl side chain. Clyclotheonamides E, E2, and E3 were more active against thrombin than against trypsin.

引用

页码：667 / 670

页数：4

共 15 条

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