Conversion of 1,3-disubstituted arenes to chiral α,α-diaryl methylammonium chlorides using arene borylation

被引：23
作者：
Boebel, Timothy A. [1 ]
Hartwig, John F. [1 ]
机构：
[1] Univ Illinois, Dept Chem, Urbana, IL 61801 USA
来源：
TETRAHEDRON | 2008年 / 64卷 / 29期
基金：
美国国家科学基金会;
关键词：
D O I：
10.1016/j.tet.2008.04.060
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A two-step conversion of 1,3-disubstituted arenes to chiral alpha,alpha-diaryl methylammonium chlorides is described. In this procedure, arenes are converted to aryl boronic esters by iridium-catalyzed borylation, and the aryl boronic esters are converted to enantioenriched amines by subsequent rhodium-catalyzed addition to chiral tert-butanesulfinimes. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：6824 / 6830
页数：7
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