Palladium-catalyzed direct phosphonation of azoles with dialkyl phosphites

被引：141

作者：

Hou, Chaodong ^{[1
,2
]}

Ren, Yunlai ^{[2
]}

Lang, Rui ^{[1
]}

Hu, Xiaoxue ^{[1
]}

Xia, Chungu ^{[1
]}

Li, Fuwei ^{[1
]}

机构：

[1] Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China

[2] Henan Univ Sci & Technol, Sch Chem Engn & Pharmaceut, Luoyang 471003, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 42期

基金：

中国国家自然科学基金;

关键词：

C-H BONDS; CROSS-COUPLING REACTIONS; DIRECT AMINATION; ARYLBORONIC ACIDS; DIRECT ALKYLATION; ARYL; MECHANISM; HALIDES; ALKYNES;

D O I：

10.1039/c2cc30429e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first Pd-catalyzed direct phosphonation of azoles with dialkyl phosphites has been achieved without addition of base or acid. This method involves the oxidative cleavage of C-H and P(O)-H bonds and represents an atom-efficiency alternative to the classical phosphonation of Ar-X. A Pd-II/Pd-IV mechanism has been studied and proposed.

引用

页码：5181 / 5183

页数：3

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