Topiramate for the treatment of juvenile myoclonic epilepsy

被引:16
作者
Sousa, PD [1 ]
De Araojo, GM [1 ]
Garzon, E [1 ]
Sakamoto, AC [1 ]
Yacubian, EMT [1 ]
机构
[1] Univ Fed Sao Paulo, Escola Paulista Med, Unidade Pesquisa & Tratamento Epilepsias, UNIFESP, Sao Paulo, Brazil
关键词
topiramate; treatment; juvenile myoclonic epilepsy;
D O I
10.1590/S0004-282X2005000500001
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Objective: The aim of this study was to evaluate the efficacy and tolerability of topiramate (TPM) in juvenile myoclonic epilepsy (JME). Method: We assessed seizure control and adverse effects of TPM in 22 patients (18 females) aged 13 to 53 years. Target TPM dosage was up to 200 mg/day. The patients were subdivided into 3 groups: those treated with seizure control plus side effects (n=4); treated with non-controlled seizures (n=15) and with JME newly diagnosed (n=3). Results: Sixteen patients completed the first year of the follow-up. Generalized tonic-clonic seizures were completely controlled in 10 (62.5%); more than 50% of reduction in 4 (25.0%) and less than 50% in 2 (12.5%). Myoclonia were controlled in 11 (68.8%) and persisted in 5 (31.2%) patients. Absence seizures were present in 5 (22.7%) of whom 2 (9.0%) showed more than 50% of seizure reduction while 3 (13.6%) presented worsening. Discontinuations were due to inadequate seizure control and adverse events (N=4), low compliance and loss of follow-up (N=2) and subject choice (N=1). Conclusion: TPM showed to be an effective and well-tolerated drug in the treatment of JME. Although frequently observed, TPM side effects were tolerable and the drug could be maintained in the majority of patients.
引用
收藏
页码:733 / 737
页数:5
相关论文
共 13 条
  • [1] A randomized, placebo-controlled study of topiramate in primary generalized tonic-clonic seizures
    Biton, V
    Montouris, GD
    Ritter, F
    Riviello, JJ
    Reife, R
    Lim, P
    Pledger, G
    [J]. NEUROLOGY, 1999, 52 (07) : 1330 - 1337
  • [2] SODIUM VALPROATE - MONOTHERAPY AND POLYTHERAPY
    COVANIS, A
    GUPTA, AK
    JEAVONS, PM
    [J]. EPILEPSIA, 1982, 23 (06) : 693 - 720
  • [3] JUVENILE MYOCLONIC EPILEPSY OF JANZ
    DELGADOESCUETA, AV
    ENRILEBACSAL, F
    [J]. NEUROLOGY, 1984, 34 (03) : 285 - 294
  • [4] Edwards JC, 2004, EPILEPSIA, V45, P139
  • [5] Topiramate in clinical practice: first year's postlicensing experience in a specialist epilepsy clinic
    Kellett, MW
    Smith, DF
    Stockton, PA
    Chadwick, DW
    [J]. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1999, 66 (06) : 759 - 763
  • [6] Kothare SV, 2004, EPILEPTIC DISORD, V6, P267
  • [7] Effectiveness of first antiepileptic drug
    Kwan, P
    Brodie, MJ
    [J]. EPILEPSIA, 2001, 42 (10) : 1255 - 1260
  • [8] LEVISOHN PM, 2003, EPILIPSIA, V44, pS267
  • [9] NIETO BM, 2002, REV NEUROL S1, V35, P88
  • [10] JUVENILE MYOCLONIC EPILEPSY - LONG-TERM RESPONSE TO THERAPY
    PENRY, JK
    DEAN, JC
    RIELA, AR
    [J]. EPILEPSIA, 1989, 30 : S19 - S23