Chemical Composition and Cytotoxic Activity of Essential Oil of Chromolaena odorata L. Growing in Togo

被引：6
|
作者：
Koba, Koffi [1 ]
Nenonene, Amen Yawo [1 ]
Catherine, Guyon [2 ]
Raynaud, Christine [3 ]
Chaumont, Jean-Pierre [2 ]
Sanda, Komla [1 ]
Laurence, Nicod [2 ]
机构：
[1] Univ Lome, Ecole Super Agron, Unite Rech Agroressources & Sante Environn, Lome, Togo
[2] Univ Franche Comte, Fac Med & Pharm, Equipe Sci Separat & Biopharmaceut 2SB, EA 479, F-25030 Besancon, France
[3] ENSIACET, INP, INRA, Lab Chim Agroind,UMR 1010, F-31077 Toulouse, France
来源：
JOURNAL OF ESSENTIAL OIL BEARING PLANTS | 2011年 / 14卷 / 04期
关键词：
Chromolaena odorata; Essential oil; beta-caryophyllene; germacrene-D; HaCaT cell line; Cytotoxicity; CONSTITUENTS; FLOWERS; GROWTH;
D O I：
10.1080/0972060X.2011.10643597
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
The leaf essential oil of Chromolaena odorata L. (Asteraceae) harvested in Togo were steam-distilled and investigated for chemical composition (GC and GC-MS) and in vitro potential cytotoxic activity on human epidermic cell line HaCat. The chemical composition showed that the main constituents of essential oil sample were respectively beta-caryophyllene (25.2 %), germacrene D (18.8 %), and linalool (7.9 %). The in vitro cytotoxicity bioassays on human cell line HaCaT did not revealed any toxicity of C. odorata essential oil up to 3000 mu L.mL(-1). Pure commercial beta-caryophyllene and germacrene D standards appeared almost non-toxic (IC(50) >3000 mu L.mL(-1)), proving the major role played by the major components in the overall cell viability showed by the C. odorata oil sample tested in this work.
引用
收藏
页码：423 / 429
页数：7
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