Mannan-binding lectin-2 (MBL2) gene polymorphisms in prenatal and perinatal cytomegalovirus infections

被引：9

作者：

Szala, Agnieszka ^{[1
]}

Paradowska, Edyta ^{[2
]}

Nowakowska, Dorota ^{[3
,4
]}

Swierzko, Anna S. ^{[1
]}

Dzierzanowska-Fangrat, Katarzyna ^{[5
]}

Sokolowska, Anna ^{[1
]}

Studzinska, Miroslawa ^{[2
]}

Gaj, Zuzanna ^{[4
]}

Suski, Patrycja ^{[2
]}

Kasztelewicz, Beata ^{[5
]}

Wilczynski, Jan ^{[3
,4
]}

Cedzynski, Maciej ^{[1
]}

机构：

[1] Polish Acad Sci, Inst Med Biol, Lab Immunobiol Infect, PL-93232 Lodz, Poland

[2] Polish Acad Sci, Inst Med Biol, Lab Mol Virol & Biol Chem, PL-93232 Lodz, Poland

[3] Med Univ Lodz, Chair Gynaecol & Obstet 3, Dept Fetal Maternal Med & Gynaecol, PL-93338 Lodz, Poland

[4] Polish Mothers Mem Hosp, Res Inst, Dept Fetal Maternal Med & Gynaecol, PL-93338 Lodz, Poland

[5] Childrens Mem Hlth Inst, Dept Clin Microbiol & Immunol, PL-04730 Warsaw, Poland

来源：

MOLECULAR IMMUNOLOGY | 2011年 / 48卷 / 15-16期

关键词：

Mannan-binding lectin; MBL2; Cytomegalovirus; Prenatal infection; Perinatal infection; DISEASE; ASSOCIATION; GENOTYPES; PATHWAY;

D O I：

10.1016/j.molimm.2011.06.220

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cytomegalovirus (CMV) is the leading cause of congenital infections among neonates. About 10% of newborns with such an infection have clinical symptoms at birth and about 1% of infected fetuses die due to developmental malformations. Mannan-binding lectin (MBL) is considered to be an important factor in innate immunity. Its deficiency is believed to predispose to various (including viral) infections. The aim of this study was to investigate the possible role of MBL2 gene polymorphisms in prenatal and perinatal CMV infections. The frequencies of MBL2 gene exon 1 mutations as well as MBL deficiency-associated variants (LXPA/O + O/O) among newborns with confirmed cytomegalovirus infection were not significantly lower than among non-infected individuals. The distribution of MBL2 haplotypes was similar between the groups studied. These data suggest MBL does not have a major influence on susceptibility to prenatal or pen natal CMV infections. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：2203 / 2206

页数：4

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