An insight into molecular mechanisms of human T helper cell differentiation

被引:69
作者
Rautajoki, Kirsi J. [1 ,2 ,4 ]
Kylaniemi, Minna K. [1 ,2 ,4 ]
Raghav, Sunil K. [1 ,2 ]
Rao, Kanury [3 ]
Lahesmaa, Riitta [1 ,2 ]
机构
[1] Abo Akad Univ, FIN-20521 Turku, Finland
[2] Univ Turku, Turku Ctr Biotechnol, FIN-20521 Turku, Finland
[3] Int Ctr Genet Engn & Biotechnol, New Delhi, India
[4] Turku Grad Sch Biomed Sci, Turku, Finland
基金
芬兰科学院;
关键词
caspase; epigenetic regulation; GATA3; IFN-gamma; IL-12; IL-4; NFAT; T cell differentiation; T-bet;
D O I
10.1080/07853890802068582
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Selective activation of T helper (Th) cell subsets plays an important role in immune response to pathogens as well as in the pathogenesis of human allergy and inflammatory diseases. Th1 cells along with the recently discovered Th17 cells play a role in the pathogenesis of autoimmune diseases. Th2 cytokines lead to series of inflammatory processes characteristic for asthma and other atopic diseases. To understand the pathogenesis of immune-mediated diseases it is crucial to dissect pathways and regulatory networks leading to the development of distinct Th subsets. Such knowledge may lead to better strategies for developing diagnostics and therapies for these diseases. The differentiation of Th1, Th2, and Th17 effector cells is driven by signals originating from T cell and costimulatory receptors as well as cytokines in the surroundings of activated naive T helper cells. There are several proteins involved in the regulation of this differentiation process. Most of the data on T helper cell differentiation have been acquired using mouse. In this review, we have summarized what is known about human T helper differentiation. In addition, selected differences between human and mouse will be discussed.
引用
收藏
页码:322 / 335
页数:14
相关论文
共 146 条
[1]   Molecular cloning, chromosome mapping and characterization of the mouse CRTH2 gene, a putative member of the leukocyte chemoattractant receptor family [J].
Abe, H ;
Takeshita, T ;
Nagata, K ;
Arita, T ;
Endo, Y ;
Fujita, T ;
Takayama, H ;
Kubo, M ;
Sugamura, K .
GENE, 1999, 227 (01) :71-77
[2]   Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17-producing human T helper cells [J].
Acosta-Rodriguez, Eva V. ;
Napolitani, Giorgio ;
Lanzavecchia, Antonio ;
Sallusto, Federica .
NATURE IMMUNOLOGY, 2007, 8 (09) :942-949
[3]   T-bet is a STAT1-induced regulator of IL-12R expression in naive CD4+ T cells [J].
Afkarian, M ;
Sedy, JR ;
Yang, J ;
Jacobson, NG ;
Cereb, N ;
Yang, SY ;
Murphy, TL ;
Murphy, KM .
NATURE IMMUNOLOGY, 2002, 3 (06) :549-557
[4]   Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation [J].
Agarwal, S ;
Rao, A .
IMMUNITY, 1998, 9 (06) :765-775
[5]   Cell-type-restricted binding of the transcription factor NFAT to a distal IL-4 enhancer in vivo [J].
Agarwal, S ;
Avni, O ;
Rao, A .
IMMUNITY, 2000, 12 (06) :643-652
[6]   Functional promoter polymorphism in the TBX21 gene associated with aspirin-induced asthma [J].
Akahoshi, M ;
Obara, K ;
Hirota, T ;
Matsuda, A ;
Hasegawa, K ;
Takahashi, N ;
Shimizu, M ;
Nakashima, K ;
Cheng, L ;
Doi, S ;
Fujiwara, H ;
Miyatake, A ;
Fujita, K ;
Higashi, N ;
Taniguchi, M ;
Enomoto, T ;
Mao, XQ ;
Nakashima, H ;
Adra, CN ;
Nakamura, Y ;
Tamari, M ;
Shirakawa, T .
HUMAN GENETICS, 2005, 117 (01) :16-26
[7]   Early activation of caspases during T lymphocyte stimulation results in selective substrate cleavage in nonapoptotic cells [J].
Alam, A ;
Cohen, LY ;
Aouad, S ;
Sékaly, RP .
JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 190 (12) :1879-1890
[8]   Direct regulation of Gata3 expression determines the T helper differentiation potential of notch [J].
Amsen, Derk ;
Antov, Andrey ;
Jankovic, Dragana ;
Sher, Alan ;
Radtke, Freddy ;
Souabni, Abdallah ;
Busslinger, Meinrad ;
McCright, Brent ;
Gridley, Thomas ;
Flavell, Richard A. .
IMMUNITY, 2007, 27 (01) :89-99
[9]   Phenotypic and functional features of human Th17 cells [J].
Annunziato, Francesco ;
Cosmi, Lorenzo ;
Santarlasci, Veronica ;
Maggi, Laura ;
Liotta, Francesco ;
Mazzinghi, Benedetta ;
Parente, Eliana ;
Fili, Lucia ;
Ferri, Simona ;
Frosali, Francesca ;
Giudici, Francesco ;
Romagnani, Paola ;
Parronchi, Paola ;
Tonelli, Francesco ;
Maggi, Enrico ;
Romagnani, Sergio .
JOURNAL OF EXPERIMENTAL MEDICINE, 2007, 204 (08) :1849-1861
[10]   An epigenetic view of helper T cell differentiation [J].
Ansel, KM ;
Lee, DU ;
Rao, A .
NATURE IMMUNOLOGY, 2003, 4 (07) :616-623