Neuromodulation in Epilepsy

被引：52

作者：

Al-Otaibi, Faisal A. ^{[1
]}

Hamani, Clement ^{[2
]}

Lozano, Andres M. ^{[2
]}

机构：

[1] King Faisal Specialist Hosp & Res Ctr, Dept Neurosci, Riyadh 11211, Saudi Arabia

[2] Toronto Western Hosp, Div Neurosurg, Toronto Western Res Inst, Toronto, ON, Canada

来源：

NEUROSURGERY | 2011年 / 69卷 / 04期

关键词：

Brain cooling; Deep-brain stimulation; Drug delivery; Epilepsy; Gene therapy; Neuromodulation; Neurostimulation; VAGUS-NERVE-STIMULATION; DEEP BRAIN-STIMULATION; TRANSCRANIAL MAGNETIC STIMULATION; CHRONIC ELECTRICAL-STIMULATION; CENTROMEDIAN THALAMIC NUCLEI; HIGH-FREQUENCY STIMULATION; MEDICALLY REFRACTORY EPILEPSY; FETAL HIPPOCAMPAL GRAFTS; GABA-PRODUCING CELLS; QUALITY-OF-LIFE;

D O I：

10.1227/NEU.0b013e31822b30cd

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Neuromodulation strategies have been proposed to treat a variety of neurological disorders, including medication-resistant epilepsy. Electrical stimulation of both central and peripheral nervous systems has emerged as a possible alternative for patients who are not deemed to be good candidates for resective procedures. In addition to well-established treatments such as vagus nerve stimulation, epilepsy centers around the world are investigating the safety and efficacy of neurostimulation at different brain targets, including the hippocampus, thalamus, and subthalamic nucleus. Also promising are the preliminary results of responsive neuromodulation studies, which involve the delivery of stimulation to the brain in response to detected epileptiform or pre-epileptiform activity. In addition to electrical stimulation, novel therapeutic methods that may open new horizons in the management of epilepsy include transcranial magnetic stimulation, focal drug delivery, cellular transplantation, and gene therapy. We review the current strategies and future applications of neuromodulation in epilepsy.

引用

页码：957 / 979

页数：23

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