Polymorphism of the HLA system and weak antibody response to BNT162b2 mRNA vaccine

被引：20

作者：

Crocchiolo, Roberto ^{[1
]}

Gallina, Anna Maria ^{[2
]}

Pani, Arianna ^{[3
,4
]}

Campisi, Daniela ^{[4
]}

Cento, Valeria ^{[3
,4
]}

Sacchi, Nicoletta ^{[2
]}

Miotti, Valeria ^{[5
]}

Gagliardi, Oscar Matteo ^{[6
]}

D'Amico, Federico ^{[7
]}

Vismara, Chiara ^{[4
]}

Cornacchini, Giorgia ^{[1
]}

Lando, Giuliana ^{[1
]}

Cuppari, Irene ^{[1
]}

Scaglione, Francesco ^{[3
,4
]}

Rossini, Silvano ^{[1
]}

机构：

[1] ASST Grande Osped Metropolitano Niguarda, Serv Immunoematol & Med Trasfus, Piazza Osped Maggiore 3, I-20162 Milan, Italy

[2] EO Osped Galliera, Italian Bone Marrow Donor Registry, Genoa, Italy

[3] Univ Milan, Dept Oncol & Hematooncol, Milan, Italy

[4] ASST Grande Osped Metropolitano Niguarda, Chem Clin & Microbiol Anal, Milan, Italy

[5] Santa Maria Misericordia Univ Hosp, Lab Immunogenet, Udine, Italy

[6] Univ Milan, Postgrad Sch Clin Pharmacol & Toxicol, Milan, Italy

[7] ASST Grande Osped Metropolitano Niguarda, Dept Infect Dis Unit, Milan, Italy

来源：

HLA | 2022年 / 99卷 / 03期

关键词：

antibody; COVID-19; HLA; mRNA vaccine; spike protein;

D O I：

10.1111/tan.14546

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The polymorphism of the HLA system has been extensively studied in COVID-19 infection, however there are no data about the role of HLA on vaccine response. We report here the HLA-A, -B, -C, and DRB1 allelic frequencies of n = 111 individuals after BNT162b2 mRNA vaccine, selected on the basis of lower antibody levels (<5% percentile) after the second dose among a total of n = 2569 vaccinees, and compare them with the frequencies of a reference population. We found that differences in the frequencies of the alleles HLA-A*03:01, A*33:03, B*58:01 and at least one haplotype (HLA-A*24:02 similar to C*07:01 similar to B*18:01 similar to DRB1*11:04) are associated with a weaker antibody response after vaccination, together with the age of vaccinees. Our results might suggest a role played by some HLA alleles or haplotypes in antibody production after the BNT162b2 mRNA vaccine, giving insights into the tracking of potentially susceptible individuals across populations. Further studies are needed to better define our exploratory findings and dissect the role of HLA polymorphism on response to anti-COVID-19 vaccines.

引用

页码：183 / 191

页数：9

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