Identifying blood-based biomarkers associated with aggression in weaned pigs after mixing

被引:7
作者
Shen, Chunyan [1 ]
Tong, Xian [1 ]
Chen, Ruonan [1 ]
Gao, Siyuan [1 ]
Liu, Xinpeng [1 ]
Schinckel, Allan P. [2 ]
Li, Yuan [1 ]
Xu, Feilong [1 ]
Zhou, Bo [1 ]
机构
[1] Nanjing Agr Univ, Coll Anim Sci & Technol, Nanjing 210095, Peoples R China
[2] Purdue Univ, Dept Anim Sci, W Lafayette, IN 47907 USA
基金
中国国家自然科学基金;
关键词
Aggressive behavior; Blood-based biomarkers; Pig; Canonical correlation analysis; Skin lesion; SEROTONIN LEVELS; BEHAVIOR; SLAUGHTER; INCREASES; DOPAMINE; ANXIETY; STRESS; PLASMA; IMPACT; BRAIN;
D O I
10.1016/j.applanim.2019.104927
中图分类号
S8 [畜牧、 动物医学、狩猎、蚕、蜂];
学科分类号
0905 ;
摘要
Animal behavior, including agonistic behavior, is regulated by various neurotransmitters and hormones in the blood. To Identify blood-based biomarkers associated with aggression in weaned pigs after mixing, a total of 500 weaned pigs from 65 litters were selected and mixed into 51 pens with littermates separately placed into different pens, and their behavior was recorded for 36 h. Blood samples were taken at 24 h before mixing and 24 h after mixing. An aggressive behavior index composite aggressive score was used to assess the aggressive behavior of weaned pigs after mixing. The most aggressive (n = 51) and the least aggressive pigs (n = 51) were selected in each pen. The concentrations of plasma triiodothyronine (T-3) in the most aggressive pigs were lower (P < 0.01) than those of the least aggressive pigs at 24 h before (3.42 vs. 5.56 ng/mL) and 24 h after regrouping (3.88 vs. 5.51 ng/mL). In addition, skin lesion scores on the front body in the most aggressive pigs was greater (Pearson Chi-Square = 14.053; P = 0.001) than those of the least aggressive pigs 2 h after mixing. The concentrations of salivary cortisol from pen at 2, 24, and 48 h after mixing were higher than that at 24 h before mixing (2.2, 1.8, 2.1 vs. 0.9 ng/mL; P < 0.05). Plasma triiodothyronine levels at - 24 (3.42 vs. 5.56 ng/mL; P < 0.05) and 24 h (3.88 vs. 5.51 ng/mL; P < 0.05) of mixing were higher in the most aggressive pigs than in the least aggressive pigs. The most aggressive pigs had less whole blood 5-hydroxytryptamine (293 vs. 330 ug/mL; P < 0.05) and more platelet number (1926 vs. 1571 x 10(9) ; P < 0.05) than the least aggressive pigs at 24 h after mixing. Number of defeat was positively related (r = 0.241, P < 0.05) to plasma tryptophan at 24 h after mixing. A significant canonical correlation (r = 0.7734, P = 0.006) was found between blood-based biomarkers and aggressive behavior indicators at 24 h before mixing. In conclusion, in this research blood-based biomarkers were partly associated with social stress-induced aggression in pigs, but the relationships are complicated.
引用
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页数:8
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共 42 条
  • [1] The effects of weight asymmetry and resource distribution on aggression in groups of unacquainted pigs
    Andersen, IL
    Andenæs, H
    Boe, KE
    Jensen, P
    Bakken, M
    [J]. APPLIED ANIMAL BEHAVIOUR SCIENCE, 2000, 68 (02) : 107 - 120
  • [2] Effect of handling on neurotransmitter profile in pig brain according to fear related behaviour
    Arroyo, Laura
    Carreras, Ricard
    Valent, Daniel
    Pena, Raquel
    Mainau, Eva
    Velarde, Antonio
    Sabria, Josefa
    Bassols, Anna
    [J]. PHYSIOLOGY & BEHAVIOR, 2016, 167 : 374 - 381
  • [3] Correlation of serotonin levels in CSF, platelets, plasma, and urine
    Audhya, Tapan
    Adams, James B.
    Johansen, Leah
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2012, 1820 (10): : 1496 - 1501
  • [4] ANDROGEN METABOLITES IMPACT CSF AMINES AND AXONAL SEROTONIN VIA MAO-A AND -B IN MALE MACAQUES
    Bethea, C. L.
    Phu, K.
    Kim, A.
    Reddy, A. P.
    [J]. NEUROSCIENCE, 2015, 301 : 576 - 589
  • [5] Type 2 Deiodinase Disruption in Astrocytes Results in Anxiety-Depressive-Like Behavior in Male Mice
    Bocco, Barbara M. L. C.
    Werneck-de-Castro, Joao Pedro
    Oliveira, Kelen C.
    Fernandes, Gustavo W.
    Fonseca, Tatiana L.
    Nascimento, Bruna P. P.
    McAninch, Elizabeth A.
    Ricci, Esther
    Kvarta-Papp, Zsuzsanna
    Fekete, Csaba
    Bernardi, Maria Martha
    Gereben, Balzs
    Bianco, Antonio C.
    Ribeiro, Miriam O.
    [J]. ENDOCRINOLOGY, 2016, 157 (09) : 3682 - 3695
  • [6] Infrared thermography of agonistic behaviour in pigs
    Boileau, Anik
    Farish, Marianne
    Turner, Simon P.
    Camerlink, Irene
    [J]. PHYSIOLOGY & BEHAVIOR, 2019, 210
  • [7] Complex contests and the influence of aggressiveness in pigs
    Camerlink, Irene
    Arnott, Gareth
    Farish, Marianne
    Turner, Simon P.
    [J]. ANIMAL BEHAVIOUR, 2016, 121 : 71 - 78
  • [8] Aggressiveness as a component of fighting ability in pigs using a game-theoretical framework
    Camerlink, Irene
    Turner, Simon P.
    Farish, Marianne
    Arnott, Gareth
    [J]. ANIMAL BEHAVIOUR, 2015, 108 : 183 - 191
  • [9] Indirect Genetic Effects and Housing Conditions in Relation to Aggressive Behaviour in Pigs
    Camerlink, Irene
    Turner, Simon P.
    Bijma, Piter
    Bolhuis, J. Elizabeth
    [J]. PLOS ONE, 2013, 8 (06):
  • [10] Identification of Single Nucleotide Polymorphisms in Porcine MAOA Gene Associated with Aggressive Behavior of Weaned Pigs after Group Mixing
    Chen, Ruonan
    Chu, Qingpo
    Shen, Chunyan
    Tong, Xian
    Gao, Siyuan
    Liu, Xinpeng
    Zhou, Bo
    Schinckel, Allan P.
    [J]. ANIMALS, 2019, 9 (11):