Tinzaparin in outpatients with pulmonary embolism or deep vein thrombosis

被引:20
作者
Dager, WE
King, JH
Branch, JM
Chow, SL
Ferrer, RE
Pak, S
Togioka, PY
White, RH
机构
[1] Univ Calif Davis, Med Ctr, Dept Pharmaceut Sci, Sacramento, CA 95817 USA
[2] Univ Calif San Francisco, Sch Pharm, San Francisco, CA 94143 USA
[3] Univ Calif Davis, Med Ctr, Dept Pharmaceut Serv, Clin Serv, Davis, CA USA
[4] Long Beach Mem Med Ctr, Long Beach, CA USA
[5] Vet Affairs Palo Alto Hlth Care Syst, Palo Alto, CA USA
[6] Univ Calif Davis, Dept Med, Davis, CA USA
关键词
deep vein thrombosis; low-molecular-weight heparin; outpatient treatment; pulmonary embolism; tinzaparin;
D O I
10.1345/aph.1E677
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
BACKGROUND: The low-molecular-weight heparins (LMWHs) have been shown to be effective in the outpatient treatment of deep vein thrombosis (DVT). Data regarding outpatient use of any LMWH in pulmonary embolism (PE) or tinzaparin in DVT while transitioning therapy to a vitamin K antagonist are limited. OBJECTIVE: To determine the safety and efficacy of tinzaparin in patients with either DVT or PE being transitioned to warfarin during LMWH therapy in the outpatient setting. METHODS: All patients who were treated with at least one outpatient dose of tinzaparin for venous thromboembolism (VTE) were identified. Charts of all patients followed within the University of California Davis healthcare system were reviewed. The incidence of bleeding and recurrent thromboembolism over a minimum of the first 4 weeks to a maximum of 12 weeks after initiating anticoagulation was assessed. RESULTS: A total of 178 patients with acute VTE were treated with tinzaparin, and outcomes could be determined in 140 cases. Forty-seven percent of these patients had objectively documented PE, Only one (07%) case of recurrent VTE was observed. Major bleeding was documented in 5 (3.6%) and minor bleeding in 8 (5.8%) patients. Two bleeding events, both major, occurred during tinzaparin therapy. CONCLUSIONS: Outpatient use of tinzaparin during transition to warfarin therapy in the treatment of VTE, including PE, appears to be feasible in patients who are judged candidates for home therapy.
引用
收藏
页码:1182 / 1187
页数:6
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