Priming with L-DOPA differently affects dynorphin and substance P mRNA levels in the striatum of 6-hydroxydopamine-lesioned rats after challenge with dopamine D1-receptor agonist

被引：22
作者：
van de Witte, SV
Drukarch, B
Stoof, JC
Voorn, P
机构：
[1] Free Univ Amsterdam, Neurosci Res Inst, Dept Anat Embryol, NL-1081 BT Amsterdam, Netherlands
[2] Free Univ Amsterdam, Neurosci Res Inst, Dept Neurol, NL-1081 BT Amsterdam, Netherlands
来源：
MOLECULAR BRAIN RESEARCH | 1998年 / 61卷 / 1-2期
关键词：
6-hydroxydopamine; dopamine receptor; basal ganglia; sensitization; turning behavior; in situ hybridization;
D O I：
10.1016/S0169-328X(98)00214-9
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
In unilaterally 6-hydroxydopamine-lesioned rats, potentiation of D1-agonist-induced turning behavior by priming with L-DOPA was correlated with changes in striatal neuropeptide mRNA levels. In non-primed rats, administration of the D1-agonist SKF-38393 markedly increased dynorphin and substance P mRNA levels in the lesioned striatum. Priming with L-DOPA dissociated the response of the two neuropeptides to the D1-agonist, with higher dynorphin and reduced substance P mRNA levels. (C) 1998 Elsevier Science B.V. All rights reserved.
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收藏
页码：219 / 223
页数：5
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