Amphiphilic γ-cyclodextrin-fullerene complexes with photodynamic activity

被引：5

作者：

Miki, Koji ^{[1
]}

Dan Zhang, Zi ^{[1
]}

Kaneko, Kaho ^{[1
]}

Kakiuchi, Yui ^{[1
]}

Kojima, Kentaro ^{[1
]}

Enomoto, Akane ^{[1
]}

Oe, Masahiro ^{[1
]}

Nogita, Kohei ^{[1
]}

Murata, Yasujiro ^{[2
]}

Harada, Hiroshi ^{[3
]}

Ohe, Kouichi ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Engn, Dept Energy & Hydrocarbon Chem, Nishikyo Ku, Kyoto 6158510, Japan

[2] Kyoto Univ, Inst Chem Res, Uji, Kyoto 6110011, Japan

[3] Kyoto Univ, Grad Sch Biostudies, Canc Cell Biol Lab, Sakyo Ku, Yoshida Konoe Cho, Kyoto 6068501, Japan

来源：

MATERIALS ADVANCES | 2022年 / 3卷 / 01期

基金：

日本科学技术振兴机构;

关键词：

HYDROPHILIC C-60 NANOPARTICLES; SINGLET OXYGEN; PHOTOPHYSICAL PROPERTIES; MOLECULAR RECOGNITION; INDOCYANINE GREEN; WATER; PHOTOSENSITIZERS; THERAPY; SOLUBILIZATION; AGGREGATION;

D O I：

10.1039/d1ma00743b

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Amphiphilic gamma-cyclodextrin-fullerene 2 : 1 complexes (CLFCH complexes) were prepared by high-speed vibration milling of lipophilic tail-grafted gamma-cyclodextrin (gamma-CD), hydrophilic tail-grafted gamma-CD and fullerene C-60. The transamidation of gamma-CD-fullerene complexes having two amino groups with lipophilic and hydrophilic activated esters also afforded amphiphilic CLFCH complexes. Self-assemblies consisting of amphiphilic CLFCH complexes efficiently generated singlet oxygen under photoirradiation. Under visible light irradiation conditions, CLFCH complexes bearing a vitamin E moiety as a lipophilic tail showed high photodynamic activity toward cancer cells.

引用

页码：312 / 317

页数：6

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