A physical map of 30,000 human genes

被引：563

作者：

Deloukas, P

Schuler, GD

Gyapay, G

Beasley, EM

Soderlund, C

Rodriguez-Tomé, P

Hui, L

Matise, TC

McKusick, KB

Beckmann, JS

Bentolila, S

Bihoreau, MT

Birren, BB

Browne, J

Butler, A

Castle, AB

Chiannilkulchai, N

Clee, C

Day, PJR

Dehejia, A

Dibling, T

Drouot, N

Duprat, S

Fizames, C

Fox, S

Gelling, S

Green, L

Harrison, P

Hocking, R

Holloway, E

Hunt, S

Keil, S

Lijnzaad, P

Louis-Dit-Sully, C

Ma, J

Mendis, A

Miller, J

Morissette, J

Muselet, D

Nusbaum, HC

Peck, A

Rozen, S

Simon, D

Slonim, DK

Staples, R

Stein, LD

Stewart, EA

Suchard, MA

Thangarajah, T

Vega-Czarny, N

机构：

[1] Sanger Ctr, Cambridge CB10 1SA, England

[2] Natl Lib Med, Natl Ctr Biotechnol Informat, NIH, Bethesda, MD 20894 USA

[3] CNRS, URA 1922, F-91000 Evry, France

[4] Stanford Univ, Sch Med, Stanford Human Genome Ctr, Dept Genet, Stanford, CA 94305 USA

[5] European Bioinformat Inst, European Mol Biol Lab Outstn, Cambridge CB10 1SD, England

[6] MIT, Whitehead Inst Biomed Res, Ctr Genome Res, Cambridge Ctr 9, Cambridge, MA 02142 USA

[7] Rockefeller Univ, Lab Stat Genet, New York, NY 10021 USA

[8] Genethon, CNRS, URA 1922, F-91000 Evry, France

[9] Univ Oxford, Nuffield Dept Clin Med, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England

[10] NIH, Lab Genet Dis Res, Natl Ctr Human Genome Res, Bethesda, MD 20892 USA

[11] CHU Laval, Ctr Rech, Quebec City, PQ G1V 4G2, Canada

[12] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA

[13] Univ Calif Los Angeles, Sch Med, Dept Biomath, Los Angeles, CA 90095 USA

[14] Res Genet, Huntsville, AL 35801 USA

[15] CNRS, UPR 420, F-94801 Villejuif, France

[16] Kazusa DNA Res Inst, Chiba 292, Japan

[17] Univ Colorado, Hlth Sci Ctr, Dept Pharmacol, Denver, CO 80262 USA

[18] Univ Colorado, Hlth Sci Ctr, Program Mol Biol, Denver, CO 80262 USA

[19] MIT, Dept Biol, Cambridge, MA 02142 USA

[20] McGill Univ, Montreal Gen Hosp, Res Inst, Montreal, PQ H3G 1A4, Canada

来源：

SCIENCE | 1998年 / 282卷 / 5389期

基金：

英国惠康基金;

关键词：

D O I：

10.1126/science.282.5389.744

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A map of 30,181 human gene-based markers was assembled and integrated with the current genetic map by radiation hybrid mapping. The new gene map contains nearly twice as many genes as the previous release, includes most genes that encode proteins of known function, and is twofold to threefold more accurate than the previous version. A redesigned, more informative and functional World Wide Web site (www.ncbi.nlm.nih.gov/genemap) provides the mapping information and associated data and annotations. This resource constitutes an important infrastructure and tool for the study of complex genetic traits, the positional cloning of disease genes, the cross-referencing of mammalian genomes, and validated human transcribed sequences for Large-scale studies of gene expression.

引用

页码：744 / 746

页数：3

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