Inhibitory action of nociceptin on spinal dorsal horn neurones of the rat, in vivo

被引：117

作者：

Stanfa, LC

Chapman, V

Kerr, N

Dickenson, AH

机构：

[1] Department of Pharmacology, University College London, London WC1E 6BT, Gower Street

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 1996年 / 118卷 / 08期

基金：

英国惠康基金;

关键词：

nociceptin; antinociception; spinal cord; wind-up; C-fibres; naloxone;

D O I：

10.1111/j.1476-5381.1996.tb15618.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Intrathecally administered nociceptin (5, 50, 225 mu g) dose-relatedly inhibited the C-fibre evoked wind-up and post-discharge of dorsal horn neurones, but not the baseline C-fibre evoked responses. Spinal naloxone 50 mu g, but not 10 mu g, reversed the effects of nociceptin. Thus the antinociceptive role of nociceptin in the spinal cord differs from that of classical opioids.

引用

收藏

页码：1875 / 1877

页数：3

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