Effect of antimicrobial compounds on Balamuthia mandrillaris encystment and human brain microvascular endothelial cell cytopathogenicity

被引：22
|
作者：
Siddiqui, Ruqaiyyah
Matin, Abdul
Warhurst, David
Stins, Monique
Khan, Naveed Ahmed [1 ]
机构：
[1] Univ London Birkbeck Coll, Sch Biol & Chem Sci, London WC1E 7HX, England
[2] Univ London, London Sch Hyg & Trop Med, London, ON, Canada
[3] Johns Hopkins Univ, Sch Med, Baltimore, MD USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2007年 / 51卷 / 12期
关键词：
D O I：
10.1128/AAC.00373-07
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Cycloheximide, ketoconazole, or preexposure of organisms to cytochalasin D prevented Balamuthia mandrillaris-associated cytopathogenicity in human brain microvascular endothelial cells, which constitute the blood-brain barrier. In an assay for inhibition of cyst production, these three agents prevented the production of cysts, suggesting that the biosynthesis of proteins and ergosterol and the polymerization of actin are important in cytopathogenicity and encystment.
引用
收藏
页码：4471 / 4473
页数：3
相关论文
共 50 条
  • [41] Nitric Oxide Inhibits Endothelial Cell Senescence in Human Microvascular Endothelial Cell Culture
    Macrea, M.
    Martin, T. J.
    Malhotra, A.
    Jia, Z.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2019, 199
  • [42] Effect of BMPRII on endothelial function in human lung microvascular endothelial cells
    Tielemans, Birger
    Gijsbers, Rik
    Michiels, Annelies
    Wagenaar, Allard
    Marti, Ricard Farre
    Belge, Catharina
    Delcroix, Marion
    Quarck, Rozenn
    EUROPEAN RESPIRATORY JOURNAL, 2018, 52
  • [43] New thiol and sulfodiimine metalloproteinase inhibitors and their effect on human microvascular endothelial cell growth
    Sang, QXA
    Jia, MC
    Schwartz, MA
    Jaye, MC
    Kleinman, HK
    Ghaffari, MA
    Luo, YL
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2000, 274 (03) : 780 - 786
  • [44] In vitro characterization of taurine transport using the human brain microvascular endothelial cell line as a human blood-brain barrier model
    Tega, Yuma
    Kawauchi, Yusuke
    Akanuma, Shin-ichi
    Inagaki, Mai
    Tachikawa, Masanori
    Hosoya, Ken-ichi
    DRUG METABOLISM AND PHARMACOKINETICS, 2025, 61
  • [45] Effect of Histophilus somni on Heart and Brain Microvascular Endothelial Cells
    O'Toole, D.
    Hunter, R.
    Allen, T.
    Zekarias, B.
    Lehmann, J.
    Kim, K. S.
    Grab, D.
    Corbeil, L. B.
    VETERINARY PATHOLOGY, 2017, 54 (04) : 629 - 639
  • [46] Human brain microvascular endothelial cell pairs model tissue-level blood-brain barrier function
    O'Connor, Blakely B.
    Grevesse, Thomas
    Zimmerman, John F.
    Ardona, Herdeline Ann M.
    Jimenez, Jorge A.
    Bitounis, Dimitrios
    Demokritou, Philip
    Parker, Kevin Kit
    INTEGRATIVE BIOLOGY, 2020, 12 (03) : 64 - 79
  • [47] Effect of hypoxia and reoxygenation on microvascular endothelial cell coupling
    Rose, K
    Bolon, M
    Ouellette, Y
    Tyml, K
    FASEB JOURNAL, 2004, 18 (04): : A627 - A627
  • [48] Effect of increased pressure on microvascular endothelial cell growth
    Klaentschi, K
    Tooke, JE
    Shore, AC
    JOURNAL OF VASCULAR RESEARCH, 1998, 35 (03) : 226 - 227
  • [49] Differentiation and freeze-thawing of human iPS cell-derived brain microvascular endothelial cells
    Yamashita, M.
    Aoki, H.
    Hashita, T.
    Iwao, T.
    Matsunaga, T.
    TOXICOLOGY LETTERS, 2019, 314 : S161 - S161
  • [50] Effects of novel mRNA-VEGF@USPIO nanoparticles on human brain microvascular endothelial cell injury
    Zhao, Jiang
    Qian, Zhiyuan
    GENERAL PHYSIOLOGY AND BIOPHYSICS, 2023, 42 (06) : 507 - 519
12345