Thymine cocrystals based on DNA-inspired binding motifs

被引：6

作者：

Koch, Elizabeth S. ^{[1
]}

McKenna, Kelly A. ^{[1
]}

Kim, Hyo Jung ^{[1
]}

Young, Victor G. ^{[2
]}

Swift, Jennifer A. ^{[1
]}

机构：

[1] Georgetown Univ, Dept Chem, 37th & O St NW, Washington, DC 20057 USA

[2] Univ Minnesota, Dept Chem, 207 Pleasant St SE, Minneapolis, MN 55455 USA

来源：

CRYSTENGCOMM | 2017年 / 19卷 / 37期

基金：

美国国家科学基金会;

关键词：

HYDROGEN-BONDED COMPLEX; CRYSTAL-STRUCTURE; MOLECULAR-STRUCTURE; NUCLEIC-ACIDS; SOLID-STATE; 9-METHYLADENINE; 1-METHYLTHYMINE; STABILIZATION; SPECTROSCOPY; CYTOSINE;

D O I：

10.1039/c7ce01347g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Nucleic acids have been recognized as an important class of biomolecules for over half a century and are an integral component of many modern pharmaceuticals. Elucidating the associations between DNA nucleobases (thymine, cytosine, adenine and guanine) and other components in both solution and the solid state has wide-ranging applications. Far fewer thymine cocrystals have been reported compared to cocrystals of the other DNA bases. Using schemes inspired by Watson-Crick base pairing motifs, herein we investigate the cocrystallization of thymine and heterocycles with complementary hydrogen bond donors and acceptors. Our coformer screen yielded three new 1 : 1 cocrystals with thymine, only two of which exhibited the expected binding motif. The difficulties encountered in this nucleobase study serve to highlight some of the special challenges associated with cocrystallization of tautomeric components.

引用

页码：5679 / 5685

页数：7

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