Growth Differentiation Factor-15 as a Biomarker for Sarcopenia in Patients With Chronic Obstructive Pulmonary Disease

被引:7
作者
Deng, Mingming [1 ,2 ,3 ,4 ,5 ]
Bian, Yiding [1 ,2 ,3 ,4 ,5 ]
Zhang, Qin [6 ]
Zhou, Xiaoming [7 ]
Hou, Gang [1 ,2 ,3 ,4 ,5 ]
机构
[1] China Japan Friendship Hosp, Ctr Resp Med, Dept Pulm & Crit Care Med, Beijing, Peoples R China
[2] Chinese Acad Med Sci, Peking Union Med Coll, Grad Sch, Beijing, Peoples R China
[3] Natl Ctr Resp Med, Beijing, Peoples R China
[4] Chinese Acad Med Sci, Inst Resp Med, Beijing, Peoples R China
[5] Natl Clin Res Ctr Resp Dis, Beijing, Peoples R China
[6] China Med Univ, Dept Pulm & Crit Care Med, Hosp 1, Shenyang, Peoples R China
[7] Chinese Acad Med Sci, Fuwai Hosp, Peking Union Med Coll, Ctr Pulm Vasc Dis,Resp Dept, Beijing, Peoples R China
来源
FRONTIERS IN NUTRITION | 2022年 / 9卷
基金
中国国家自然科学基金;
关键词
chronic obstructive pulmonary disease; sarcopenia; GDF15; biomarker; nomogram; LUNG EPITHELIAL-CELLS; FUNCTIONAL PERFORMANCE; MUSCLE STRENGTH; COPD; ASSOCIATIONS; INFLAMMATION; PREVALENCE; DIAGNOSIS; CYTOKINE; DISTANCE;
D O I
10.3389/fnut.2022.897097
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
PurposeSarcopenia is an important factor contributing to comorbidities in patients with chronic obstructive pulmonary disease (COPD) and is an independent risk factor for increased mortality. The diagnostic process for sarcopenia requires specific equipment and specialized training and is difficult procedurally. A previous study found that GDF15 levels are associated with skeletal muscle mass and function in patients with COPD. However, whether circulating GDF15 levels can be used for the prediction of sarcopenia in patients with COPD is unknown. MethodsThis study included 235 patients with stable COPD who were divided into a development set (n = 117) and a validation set (n = 118), and we followed the definition of sarcopenia as defined by the guidelines from the Asian Working Group for Sarcopenia. Serum concentrations of GDF15 were measured using an enzyme-linked immunosorbent assay (ELISA), and construction of a nomogram and decision curve analysis were performed using the R package "rms." ResultsIn this study, serum GDF15 levels were negatively associated with skeletal muscle mass (r = -0.204, p = 0.031), handgrip strength (r = -0.274, p = 0.004), quadriceps strength (r = -0.269, p = 0.029), and the thickness (r = -0.338, p < 0.001) and area (r = -0.335, p < 0.001) of the rectus femoris muscle in patients with COPD. Furthermore, the serum levels of GDF15 in patients with sarcopenia were significantly higher than those in controls. Importantly, serum levels of GDF15 could effectively predict sarcopenia in patients with COPD based on the development set (AUC = 0.827) and validation set (AUC = 0.801). Finally, a nomogram model based on serum GDF15 levels and clinical features showed good predictive ability (AUC > 0.89) in the development and validation sets. ConclusionSerum GDF15 levels could be used to accurately and easily evaluate sarcopenia in patients with COPD.
引用
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页数:11
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