Telomeres and telomerase as targeted therapies in cancer treatment

被引：1

作者：

Souiden, Y. ^{[1
]}

Bouraoui, A. ^{[2
]}

Chaieb, K. ^{[1
]}

Mahdouani, K. ^{[1
]}

机构：

[1] Hop Ibn El Jazzar, Mol Biol Lab, Kairouan 3140, Tunisia

[2] Fac Pharm, Unite Rech Ursam, Monastir, Tunisia

来源：

BULLETIN DU CANCER | 2010年 / 97卷 / 09期

关键词：

telomere; telomerase; G-quadruplex; telomerase-targeted cancer therapy; CELLS IN-VITRO; REVERSE-TRANSCRIPTASE; HAMMERHEAD RIBOZYME; C-MYC; MEDIATED INHIBITION; ANTICANCER THERAPY; ANTITUMOR-ACTIVITY; HTERT EXPRESSION; GENE-EXPRESSION; 2-5A ANTISENSE;

D O I：

10.1684/bdc.2010.1155

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Advances in chromosome dynamics have increased our understanding of the significant role of telomeres and telomerase in cancer. Telomerase is expressed in almost all cancer cells but is inactive in most normal somatic cells. Therefore, telomerase is an important target for the design of therapeutic agents that might have minimal side effects. Herein, we evaluate current approaches to telomerase/telomere-targeted therapy, discuss the benefits and disadvantages, and speculate on the future direction of telomerase inhibitors as cancer therapeutics.

引用

页码：1087 / 1104

页数：18

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