MLL/GAS7 fusion in a pediatric case of t(11;17)(q23;p13)-positive precursor B-cell acute lymphoblastic leukemia

被引：0

作者：

Panagopoulos, Ioannis ^{[1
]}

Lilljebjorn, Henrik ^{[1
]}

Strombeck, Bodil ^{[1
]}

Hjorth, Lars ^{[2
]}

Olofsson, Tor ^{[3
]}

Johansson, Bertil ^{[1
]}

机构：

[1] Univ Hosp, Dept Clin Genet, S-22185 Lund, Sweden

[2] Univ Hosp, Dept Pediat, Lund, Sweden

[3] Univ Hosp, Dept Hematol, Lund, Sweden

来源：

HAEMATOLOGICA | 2006年 / 91卷 / 09期

基金：

瑞典研究理事会;

关键词：

ALL; translocation; MLL; GAS7; fusion;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

MLL/GAS7, resulting from t(11;17)(q23;p13), has been reported in one case of treatment-related acute myeloid leukemia (AML). We present a de novo case of t(11;17)-positive pediatric acute lymphoblastic leukemia. Fluorescent in situ hybridization and reverse transcriptase polymerase chain reaction analyses revealed an MLL/GAS7 chimera identical to the one previously described in AML. The molecular genetic features of MLL/GAS7 and the clinical impact of t(11;17) are discussed.

引用

页码：1287 / 1288

页数：2

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