Pituitary adenylate cyclase activating polypeptide and vasoactive intestinal peptide inhibit feeding in the chick brain by different mechanisms

被引：33
|
作者：
Tachibana, T [1 ]
Tomonaga, S
Oikawa, D
Saito, S
Takagi, T
Saito, ES
Boswell, T
Furuse, M
机构：
[1] Kyushu Univ, Grad Sch Bioresource & Bioenvironm Sci, Lab Adv Anim & Marine Bioresources, Fukuoka 8128581, Japan
[2] Roslin Inst, Div Integrat Biol, Roslin EH25 9PS, Midlothian, Scotland
来源：
NEUROSCIENCE LETTERS | 2003年 / 348卷 / 01期
基金：
日本学术振兴会;
关键词：
chick; feeding; intracerebroventricular injection; pituitary adenylate cyclase 1 receptor; pituitary adenylate cyclase-activating polypeptide; vasoactive intestinal peptide; VPAC receptor;
D O I：
10.1016/S0304-3940(03)00646-3
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Intracerebroventricular (ICV) injections of pituitary adenylate cyclase-activating polypeptide-38 (PACAP) and vasoactive intestinal peptide (VIP) inhibit feeding in chicks. However, the precise anorexigenic mechanisms have not been investigated, since both peptides activate the VPAC receptor in mammals. We investigated which receptor mediates the anorexigenic effects of these peptides in chicks. ICV co-injection of PACAP (6-38), a PAC1 receptor antagonist, attenuated the anorexigenic effect of PACAP but not VIP. On the other hand, ICV co-injection of [D-p-Cl-Phe6, Leu17]-VIP, a VPAC receptor antagonist, did not affect the effects of both peptides. Although these results imply that the effect of VIP was not specific, a subsequent experiment demonstrated that ICV injection of anti-chicken VIP antiserum stimulated feeding and suggested that endogenous VIP inhibits feeding in the chick brain. Collectively, the data suggest that the anorexigenic mechanism of PACAP is different from that of VIP and that an undiscovered VIP receptor may be present in the chicken brain. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.
引用
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页码：25 / 28
页数：4
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