Polymorphism in interleukin-6 gene is associated with bone mineral density in patients with adolescent idiopathic scoliosis

被引:20
作者
Lee, J. S. [1 ]
Suh, K. T. [1 ]
Eun, I. S. [1 ]
机构
[1] Pusan Natl Univ, Sch Med, Pusan, South Korea
来源
JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME | 2010年 / 92B卷 / 08期
基金
加拿大健康研究院;
关键词
POLYMERASE-CHAIN-REACTION; POSTMENOPAUSAL WOMEN; PROMOTER REGION; RECEPTOR GENE; FRACTURE RISK; OSTEOPOROSIS; VARIANT; SUSCEPTIBILITY; OSTEOPENIA; INDEX;
D O I
10.1302/0301-620X.92B8.23676
中图分类号
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学(修复外科学)];
学科分类号
摘要
Low bone mass and osteopenia have been described in the axial and peripheral skeleton of patients with adolescent idiopathic scoliosis (AIS). Recently, many studies have shown that gene polymorphism is related to osteoporosis. However, no studies have linked the association between IL6 gene polymorphism and bone mass in AIS. This study examined the association between bone mass and IL6 gene polymorphism in 198 girls with AIS. The polymorphisms of IL6-597 G -> A, IL6-572 G -> C and IL6-174 G -> A and the bone mineral density in the lumbar spine and femoral neck were analysed and compared with their levels in healthy controls. The mean bone mineral density at both sites in patients with AIS was decreased compared with controls (p = 0.0022 and p = 0.0013, respectively). Comparison of genotype frequencies between AIS and healthy controls revealed a statistically significant difference in IL6-572 G -> C polymorphism (p = 0.0305). There was a significant association between the IL6-572 G -> C polymorphism and bone mineral density in the lumbar spine, with the CC genotype significantly higher with the GC (p = 0.0124) or GG (p = 0.0066) genotypes. These results suggest that the IL6-572 G -> C polymorphism is associated with bone mineral density in the lumbar spine in Korean girls with AIS.
引用
收藏
页码:1118 / 1122
页数:5
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