Platinum-Decorated Gold Nanoparticles with Dual Functionalities for Ultrasensitive Colorimetric in Vitro Diagnostics

被引:284
作者
Gao, Zhuangqiang [1 ,2 ]
Ye, Haihang [1 ]
Tang, Dianyong [3 ]
Tao, Jing [4 ]
Habibi, Sanaz [5 ]
Minerick, Adrienne [5 ]
Tang, Dianping [2 ]
Xia, Xiaohu [1 ]
机构
[1] Michigan Technol Univ, Dept Chem, Houghton, MI 49931 USA
[2] Fuzhou Univ, Key Lab Anal & Detect Food Safety, Fujian Prov & Minist Educ,Dept Chem, Collaborat Innovat Ctr Detect Technol Haixi Food, Fuzhou 350108, Fujian, Peoples R China
[3] Chongqing Univ Arts & Sci, Int Acad Targeted Therapeut & Innovat, Chongqing 402160, Peoples R China
[4] Brookhaven Natl Lab, Condensed Matter Phys & Mat Sci Dept, Upton, NY 11973 USA
[5] Michigan Technol Univ, Dept Chem Engn, Houghton, MI 49931 USA
基金
美国国家科学基金会;
关键词
In vitro diagnostics; gold nanoparticles; seeded growth; detection; biomarker; SURFACE-PLASMON RESONANCE; COLLOIDAL METAL NANOCRYSTALS; SEED-MEDIATED GROWTH; OPTICAL-PROPERTIES; HORSERADISH-PEROXIDASE; CARE DIAGNOSTICS; VISUAL DETECTION; TROPONIN-I; REAL-TIME; NAKED EYE;
D O I
10.1021/acs.nanolett.7b02385
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Au nanoparticles (AuNPs) as signal reporters have been utilized in colorimetric in vitro diagnostics (IVDs) for decades. Nevertheless, it remains a grand challenge to substantially enhance the detection sensitivity of AuNP-based IVDs as confined by the inherent plasmonics of AuNPs. In this work, we circumvent this confinement by developing unique dual-functional AuNPs that were engineered by coating conventional AuNPs with ultrathin Pt skins of sub-10 atomic layers (i.e., Au@Pt NPs). The Au@Pt NPs retain the plasmonic activity of initial AuNPs while possessing ultrahigh catalytic activity enabled by Pt skins. Such dual functionalities, plasmonics and catalysis, offer two different detection alternatives: one produced just by the color from plasmonics (low-sensitivity mode) and the second more sensitive color catalyzed from chromogenic substrates (high-sensitivity mode), achieving an "on-demand" tuning of the detection performance. Using lateral flow assay as model IVD platform and conventional AuNPs as a benchmark, we demonstrate that the Au@Pt NPs could enhance detection sensitivity by 2 orders of magnitude.
引用
收藏
页码:5572 / 5579
页数:8
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