Hematopoietic Stem Cell Transplantation for Severe Combined Immunodeficiency (SCID)

被引：30

作者：

Haddad, Elie ^{[1
]}

Hoenig, Manfred ^{[2
]}

机构：

[1] Univ Montreal, CHU St Justine, Dept Pediat Microbiol Immunol & Infect Dis, Montreal, PQ, Canada

[2] Univ Med Ctr Ulm, Dept Pediat, Ulm, Germany

来源：

FRONTIERS IN PEDIATRICS | 2019年 / 7卷

关键词：

severe combined immunodeficiency; SCID; clinical presentation; infections; hematopoietic stem cell transplantation; HSCT; TERM IMMUNE RECONSTITUTION; OMENN SYNDROME; SINGLE-CENTER; DISEASE; CHILDREN; SURVIVAL; COHORT;

D O I：

10.3389/fped.2019.00481

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Severe Combined Immunodeficiencies (SCID) are a heterogeneous group of monogenetic diseases. We describe the typical clinical presentation of patients with SCID as well as basic principles in diagnosis and therapy by hematopoietic stem cell transplantation. Therapeutic strategies may differ between subtypes and the inherent reduced capacity or inablility to reject a graft have to be considered.

引用

页数：5