Effect of chitosan-polyvinyl alcohol blend nanofibrous web on the healing of excision and incision full thickness wounds

被引：18

作者：

Kanani, A. G. ^{[1
]}

Bahrami, S. H. ^{[1
]}

Taftei, H. A. ^{[2
]}

Rabbani, S. ^{[2
]}

Sotoudeh, M. ^{[2
]}

机构：

[1] Amir Kabir Univ Technol, Dept Text Engn, Tehran, Iran

[2] Univ Tehran Med Sci, Tehran Heart Ctr, Tehran, Iran

来源：

IET NANOBIOTECHNOLOGY | 2010年 / 4卷 / 04期

关键词：

GROWTH-FACTOR; GRANULATION-TISSUE; POLYMER NANOFIBERS; ELECTROSPUN; KERATINOCYTES; MICE; SKIN; RELEASE; FIBERS; REPAIR;

D O I：

10.1049/iet-nbt.2010.0004

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Chitosan-polyvinyl alcohol (PVA) blend nanofibrous webs were fabricated in different blend ratios through electrospinning procedures. From scanning electron microscopy (SEM) results, 25/75 blend ratio of chitosan-PVA was selected for biological studies. In vivo studies were carried out on the dorsum of rats of two types: longitudinal incisional wounds (n = 8 rats) and round excisional wounds (n = 8). Pathological study was done on the wounds to investigate the healing process. The histological study in wound healing indicated that the administration of chitosan nanofibrous web improved the wound healing, qualitatively and quantitatively.

引用

页码：109 / 117

页数：9

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