Abnormal regional homogeneity as potential imaging biomarker for psychosis risk syndrome: a resting-state fMRI study and support vector machine analysis

被引:56
作者
Wang, Shuai [1 ]
Wang, Guodong [1 ]
Lv, Hailong [1 ]
Wu, Renrong [1 ]
Zhao, Jingping [1 ,2 ]
Guo, Wenbin [1 ]
机构
[1] Cent South Univ, Xiangya Hosp 2, China Natl Clin Res Ctr Mental Hlth Disorders,Men, Natl Technol Inst Psychiat,Key Lab Psychiat & Men, Changsha 410011, Hunan, Peoples R China
[2] Xinxiang Med Univ, Affiliated Hosp 2, Henan Key Lab Biol Psychiat, Henan Mental Hosp, Xinxiang 453002, Peoples R China
关键词
GRAY-MATTER VOLUME; ULTRA-HIGH-RISK; CLINICAL HIGH-RISK; TEMPORAL GYRUS; AT-RISK; FUNCTIONAL CONNECTIVITY; CHRONIC-SCHIZOPHRENIA; 1ST-EPISODE SCHIZOPHRENIA; 1ST-DEGREE RELATIVES; BRAIN ABNORMALITIES;
D O I
10.1038/srep27619
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Subjects with psychosis risk syndrome (PRS) have structural and functional abnormalities in several brain regions. However, regional functional synchronization of PRS has not been clarified. We recruited 34 PRS subjects and 37 healthy controls. Regional homogeneity (ReHo) of resting-state functional magnetic resonance scans was employed to analyze regional functional synchronization in these participants. Receiver operating characteristic curves and support vector machines were used to detect whether abnormal regional functional synchronization could be utilized to separate PRS subjects from healthy controls. We observed that PRS subjects showed significant ReHo decreases in the left inferior temporal gyrus and increases in the right inferior frontal gyrus and right putamen compared with the controls. No correlations between abnormal regional functional synchronization in these brain regions and clinical characteristics existed. A combination of the ReHo values in the three brain regions showed sensitivity, specificity, and accuracy of 88.24%, 91.89%, and 90.14%, respectively, for discriminating PRS subjects from healthy controls. We inferred that abnormal regional functional synchronization exists in the cerebrum of PRS subjects, and a combination of ReHo values in these abnormal regions could be applied as potential image biomarker to identify PRS subjects from healthy controls.
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页数:8
相关论文
共 54 条
[1]   Decreased striatal dopaminergic innervation in REM sleep behavior disorder [J].
Albin, RL ;
Koeppe, RA ;
Chervin, RD ;
Consens, FB ;
Wernette, K ;
Frey, KA ;
Aldrich, MS .
NEUROLOGY, 2000, 55 (09) :1410-1412
[2]   Altered Prefrontal and Hippocampal Function During Verbal Encoding and Recognition in People With Prodromal Symptoms of Psychosis [J].
Allen, Paul ;
Seal, Marc L. ;
Valli, Isabel ;
Fusar-Poli, Paolo ;
Perlini, Cinzia ;
Day, Fern ;
Wood, Stephen J. ;
Williams, Steven C. ;
McGuire, Philip K. .
SCHIZOPHRENIA BULLETIN, 2011, 37 (04) :746-756
[3]   FUNCTIONAL CONNECTIVITY IN THE MOTOR CORTEX OF RESTING HUMAN BRAIN USING ECHO-PLANAR MRI [J].
BISWAL, B ;
YETKIN, FZ ;
HAUGHTON, VM ;
HYDE, JS .
MAGNETIC RESONANCE IN MEDICINE, 1995, 34 (04) :537-541
[4]   Regional gray matter volume abnormalities in the at risk mental state [J].
Borgwardt, Stefan J. ;
Riecher-Roessler, Anita ;
Dazzan, Paola ;
Chitnis, Xavier ;
Aston, Jacqueline ;
Drewe, Margret ;
Gschwandtner, Ute ;
Haller, Sven ;
Pflueger, Marlon ;
Rechsteiner, Evelyne ;
D'Souza, Marcus ;
Stieglitz, Rolf-Dieter ;
Radu, Ernst-Wilhelm ;
McGuire, Philip K. .
BIOLOGICAL PSYCHIATRY, 2007, 61 (10) :1148-1156
[5]   Neural correlates of executive function and working memory in the 'at-risk mental state' [J].
Broome, Matthew R. ;
Matthiasson, Pall ;
Fusar-Poli, Paolo ;
Woolley, James B. ;
Johns, Louise C. ;
Tabraham, Paul ;
Bramon, Elvira ;
Valmaggia, Lucia ;
Williams, Steven C. R. ;
Brammer, Michael J. ;
Chitnis, Xavier ;
McGuire, Philip K. .
BRITISH JOURNAL OF PSYCHIATRY, 2009, 194 (01) :25-33
[6]  
Buckner Randy L, 2013, Dialogues Clin Neurosci, V15, P351
[7]  
Cao Qing-jiu, 2007, Beijing Da Xue Xue Bao Yi Xue Ban, V39, P261
[8]   LIBSVM: A Library for Support Vector Machines [J].
Chang, Chih-Chung ;
Lin, Chih-Jen .
ACM TRANSACTIONS ON INTELLIGENT SYSTEMS AND TECHNOLOGY, 2011, 2 (03)
[9]  
ChaoGan Y., 2010, FRONTIERS IN SYSTEMS NEUROSCIENCE, V4, P13, DOI [DOI 10.3389/FNSYS.2010.00013, 10.3389/fnsys.2010.00013]
[10]   Superior Temporal Lobe Dysfunction and Frontotemporal Dysconnectivity in Subjects at Risk of Psychosis and in First-Episode Psychosis [J].
Crossley, Nicolas A. ;
Mechelli, Andrea ;
Fusar-Poli, Paolo ;
Broome, Matthew R. ;
Matthiasson, Pall ;
Johns, Louise C. ;
Bramon, Elvira ;
Valmaggia, Lucia ;
Williams, Steven C. R. ;
McGuire, Philip K. .
HUMAN BRAIN MAPPING, 2009, 30 (12) :4129-4137