Synthesis and characterization of platinum(II) oxadiazoline complexes and their in vitro antitumor activity in platinum-sensitive and -resistant cancer cell lines

被引：52

作者：

Coley, Helen M. ^{[1
]}

Sarju, Julien ^{[2
]}

Wagner, Gabriele ^{[2
]}

机构：

[1] Univ Surrey, Postgrad Med Sch, Guildford GU2 7XH, Surrey, England

[2] Univ Surrey, Div Chem, SBMS, Guildford GU2 7XH, Surrey, England

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2008年 / 51卷 / 01期

关键词：

D O I：

10.1021/jm061263s

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of platinum(II) complexes bearing Delta(4)-1,2,4-oxadiazoline ligands have been synthesized and characterized. Their in vitro antitumor activity has been assessed in platinum-sensitive and -resistant human ovarian cancer cell lines (PEO1, PEOCisR, PEOCarboR, and SK-OV3), as well as in colon cancer (SW948) and testicular cancer cell lines (N-TERA). All compounds tested showed potent cytotoxicity in the platinum-sensitive cell lines and retained activity in the cisplatin- and carboplatin-resistant lines, with IC50 values similar to the parental drug sensitive counterpart. We propose, therefore, that platinum(II) oxadiazoline complexes may possess a novel mechanism of action, which render them active in tumor cells, with resistance to currently used platinum anticancer agents.

引用

页码：135 / 141

页数：7

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