Exosomes in the pathogenesis and treatment of ocular diseases

被引:10
作者
Zhang, Zhihan [1 ]
Liang, Xiaotian [1 ]
Zhou, Jing [1 ]
Meng, Meijun [1 ]
Gao, Ya [1 ]
Yi, Guoguo [2 ]
Fu, Min [3 ]
机构
[1] Southern Med Univ, Guangzhou, Guangdong, Peoples R China
[2] Sun Yat Sen Univ, Dept Ophthalmol, Affiliated Hosp 6, Guangzhou, Guangdong, Peoples R China
[3] Southern Med Univ, Zhujiang Hosp, Dept Ophthalmol, Guangzhou, Guangdong, Peoples R China
关键词
Exosomes; Eye diseases; Treatment; Pathogenesis; Biomarkers; Stem cells; RETINAL-PIGMENT EPITHELIUM; MESENCHYMAL STEM-CELLS; VESICLES PROMOTE NEUROPROTECTION; BLUE-LIGHT STIMULATION; EXTRACELLULAR VESICLES; MICRORNA EXPRESSION; ALPHA-CRYSTALLINS; ENDOTHELIAL-CELLS; IMMUNE-RESPONSES; AQUEOUS-HUMOR;
D O I
10.1016/j.exer.2021.108626
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Exosomes have diverse functions and rich content and are involved in intercellular communication, immune regulation, viral infection, tissue regeneration, and the occurrence, development and metastasis of tumours. Notably, various stem cell-derived exosomes are expected to become new therapeutic approaches for inflammatory diseases and tumours and have good clinical application prospects. However, few studies have examined exosomes in ophthalmic diseases. Therefore, based on the functions of exosomes, this paper summarizes progress in the possible use of exosomes as treatment for specific ophthalmic diseases, aiming to determine the pathogenesis of exosomes to achieve more effective clinical diagnosis and treatment of these diseases.
引用
收藏
页数:12
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